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CDK6 protein, human

Known as: cyclin-dependent kinase 6, human, PLSTIRE protein, human, Serine/Threonine-Protein Kinase PLSTIRE 
Cyclin-dependent kinase 6 (326 aa, ~37 kDa) is encoded by the human CDK6 gene. This protein plays a role in both protein phosphorylation and cell… 
National Institutes of Health

Related topics

Related topics

18 relations
CDK6 geneCell CycleCell Cycle ControlCell Nucleus

Broader (1)

cyclin-dependent kinase 6

Papers overview

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Highly Cited
2015
Highly Cited
2015
Brain Exposure of Two Selective Dual CDK4 and CDK6 Inhibitors and the Antitumor Activity of CDK4 and CDK6 Inhibition in Combination with Temozolomide in an Intracranial Glioblastoma Xenograft
Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6… 
Highly Cited
2013
Highly Cited
2013
Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.
Chromosomal rearrangements involving the H3K4 methyltransferase mixed-lineage leukemia (MLL) trigger aberrant gene expression in… 
Highly Cited
2011
Highly Cited
2011
MicroRNA-26a/b and their host genes cooperate to inhibit the G1/S transition by activating the pRb protein
The functional association between intronic miRNAs and their host genes is still largely unknown. We found that three gene loci… 
Highly Cited
2010
Highly Cited
2010
microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma.
Mantle cell lymphoma (MCL) is one of the most aggressive B-cell lymphomas. Although several protein-coding genes are altered… 
Highly Cited
2010
Highly Cited
2010
miR-129 regulates cell proliferation by downregulating Cdk6 expression.
Reduced expression of miR-129 has been reported in multiple tumor cell lines and in primary tumors including medulloblastoma… 
Review
2005
Review
2005
CAK—Cyclin-Dependent Activating Kinase: A Key Kinase in Cell Cycle Control and a Target for Drugs?
The Cyclin-dependent kinase (CDK) Activating Kinase (CAK) is responsible for the activating phosphorylation of CDK1, CDK2, CDK4… 
Highly Cited
2000
Highly Cited
2000
The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent… 
Highly Cited
1999
Highly Cited
1999
Cyclin D-CDK Subunit Arrangement Is Dependent on the Availability of Competing INK4 and p21 Class Inhibitors
ABSTRACT The D-type cyclins and their major kinase partners CDK4 and CDK6 regulate G0-G1-S progression by contributing to the… 
Highly Cited
1995
Highly Cited
1995
Both p16 and p21 Families of Cyclin-dependent Kinase (CDK) Inhibitors Block the Phosphorylation of Cyclin-dependent Kinases by the CDK-activating Kinase (*)
Phosphorylation of cyclin-dependent kinases (CDKs) by the CDK-activating kinase is required for the activation of CDK enzymes… 
Highly Cited
1994
Highly Cited
1994
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
A family of vertebrate cdc2-related kinases has been identified, and these kinases are candidates for roles in cell cycle… 
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