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Troxerutin protects against high cholesterol-induced cognitive deficits in mice.

• Jun Lu, Dong-Mei Wu, Zi-hui Zheng, Yuanlin Zheng, Bin Hu, Zi-feng Zhang
• Brain : a journal of neurology
• 2011

Recent findings suggest that neurotoxicity is the mechanism underlying the induction of neuronal insulin resistance by a high cholesterol diet. Troxerutin, a naturally occurring flavonoid, has been… (More)

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice.

• Jun Lu, Dong-Mei Wu, +4 authors Qun Shan
• Brain, behavior, and immunity
• 2011

Evidence suggests that obesity-induced cognitive impairments are driven by in brain inflammatory responses and inflammation-mediated brain insulin resistance. Ursolic acid (UA), a triterpenoid… (More)

Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.

• Jun Lu, Dong-Mei Wu, +6 authors Yong-jian Wang
• Cerebral cortex
• 2010

Evidence shows that administration of D-galactose (D-gal) induces reactive oxygen species (ROS) production and inflammatory response resulting in neurodegenerative changes. Ursolic acid (UA), a… (More)

Luteoloside Suppresses Proliferation and Metastasis of Hepatocellular Carcinoma Cells by Inhibition of NLRP3 Inflammasome

• Shao-hua Fan, Yanyan Wang, +7 authors Qun Shan
• PloS one
• 2014

The inflammasome is a multi-protein complex which when activated regulates caspase-1 activation and IL-1β secretion. Inflammasome activation is mediated by NLR proteins that respond to stimuli. Among… (More)

Purple sweet potato color alleviates D-galactose-induced brain aging in old mice by promoting survival of neurons via PI3K pathway and inhibiting cytochrome C-mediated apoptosis.

• Jun Lu, Dong-Mei Wu, Yuanlin Zheng, Bin Hu, Zi-feng Zhang
• Brain pathology
• 2010

Purple sweet potato color (PSPC), a class of naturally occurring anthocyanins, protects brain function against oxidative stress induced by D-galactose (D-gal) (Sigma-Aldrich, St. Louis, MO, USA). Our… (More)

Troxerutin protects the mouse liver against oxidative stress-mediated injury induced by D-galactose.

• Zi-feng Zhang, Shao-hua Fan, +4 authors Bin Hu
• Journal of agricultural and food chemistry
• 2009

Troxerutin, a trihydroxyethylated derivative of rutin, has been well-demonstrated to exert hepatoprotective properties. In the present study, we attempted to explore whether the antioxidant and… (More)

CERS2 suppresses tumor cell invasion and is associated with decreased V-ATPase and MMP-2/MMP-9 activities in breast cancer.

• Shao-hua Fan, Yanyan Wang, +7 authors Wei Cheng
• Journal of cellular biochemistry
• 2015

Ceramide synthase 2 (CERS2) is the gene identified from a human liver cDNA library in 2001. Our previous studies have shown higher expression of CERS2 in the breast cancer patients was associated… (More)

Ursolic acid improves domoic acid-induced cognitive deficits in mice.

• Dong-Mei Wu, Jun Lu, +5 authors Meng-qiu Li
• Toxicology and applied pharmacology
• 2013

Our previous findings suggest that mitochondrial dysfunction is the mechanism underlying cognitive deficits induced by domoic acid (DA). Ursolic acid (UA), a natural triterpenoid compound, possesses… (More)

NGF-Dependent activation of TrkA pathway: A mechanism for the neuroprotective effect of troxerutin in D-galactose-treated mice.

• Jun Lu, Dong-Mei Wu, Bin Hu, Yuanlin Zheng, Zi-feng Zhang, Yong-jian Wang
• Brain pathology
• 2010

D-galactose-(D-gal)-treated mouse, with cognitive impairment, has been used for neurotoxicity investigation and anti-neurotoxicity pharmacology research. In this study, we investigated the mechanism… (More)

Purple sweet potato color protects mouse liver against d-galactose-induced apoptosis via inhibiting caspase-3 activation and enhancing PI3K/Akt pathway.

• Zi-feng Zhang, Jun Lu, +6 authors Chan-Min Liu
• Food and chemical toxicology : an international…
• 2010

Purple sweet potato color (PSPC) has been shown to possess hepatoprotective effects in our previous study. To clarify the detailed mechanism of hepatoprotective effects of PSPC, we investigated the… (More)

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