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Quercetin protects rat liver against lead-induced oxidative stress and apoptosis.
Quercetin reverses d-galactose induced neurotoxicity in mouse brain
Troxerutin protects the mouse kidney from d-galactose-caused injury through anti-inflammation and anti-oxidation.
Purple sweet potato color attenuates oxidative stress and inflammatory response induced by d-galactose in mouse liver.
Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice
Ursolic acid attenuates D-galactose-induced inflammatory response in mouse prefrontal cortex through inhibiting AGEs/RAGE/NF-κB pathway activation.
Ursolic acid administration significantly improved behavioral performance of D-gal-treated mice in step-through test and Morris water maze task and significantly decreased AGEs induced the expression of receptor for advanced glycation end products and inhibited NF-κB p65 nuclear translocation in the prefrontal cortex of D -gal- treated mice.
Purple Sweet Potato Color Alleviates D‐galactose‐induced Brain Aging in Old Mice by Promoting Survival of Neurons via PI3K Pathway and Inhibiting Cytochrome C‐mediated Apoptosis
- Jun Lu, Dong-Mei Wu, Yuanlin Zheng, Bin Hu, Zi‐feng Zhang
- Biology, ChemistryBrain pathology
- 1 May 2010
It was demonstrated that phosphoinositide 3‐kinase (PI3K) activation was required for PSPC to promote the neuronal survival accompanied with phosphorylation and activation of Akt and p44/42 mitogen‐activated protein kinase (MAPK) by using PI3K inhibitor LY294002 by using a neuronal survival mechanism.
Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.
Chronic administration of troxerutin protects mouse brain against d-galactose-induced impairment of cholinergic system
Dynamic conformational changes of extracellular S5–P linkers in the hERG channel
It is proposed that the four S5–P linkers in a hERG channel can engage in dynamic conformational changes during channel gating, and interactions between S5-P linker from neighbouring subunits contribute importantly to channel inactivation.