The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2

@article{Ojala2000TheAV,
  title={The apoptotic v-cyclin–CDK6 complex phosphorylates and inactivates Bcl-2},
  author={P{\"a}ivi M Ojala and Kazuhito Yamamoto and Esmeralda Casta{\~n}os-V{\'e}lez and Peter Biberfeld and S Stanley J. Korsmeyer and Tomi P. M{\"a}kel{\"a}},
  journal={Nature Cell Biology},
  year={2000},
  volume={2},
  pages={819-825}
}
v-cyclin encoded by Kaposi's sarcoma herpesvirus/human herpesvirus 8 (KSHV or HHV8) associates with cellular cyclin-dependent kinase 6 (CDK6) to form a kinase complex that promotes cell-cycle progression, but can also induce apoptosis in cells with high levels of CDK6. Here we show that whereas HHV8-encoded v-Bcl-2 protects against this apoptosis, cellular Bcl-2 has lost its anti-apoptotic potential as a result of an inactivating phosphorylation in its unstructured loop region. Moreover, we… CONTINUE READING