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CCL21 protein, human

Known as: Small Inducible Cytokine A21, C-C Motif Chemokine 21, 6Ckine 
C-C motif chemokine 21 (134 aa, ~15 kDa) is encoded by the human CCL21 gene. This protein plays a role in both the negative regulation of… 
National Institutes of Health

Related topics

Related topics

15 relations
Biologic DevelopmentCCL21 geneCCL21 wt AlleleCentral Nervous System

Narrower (1)

Recombinant Secondary Lymphoid-Tissue Chemokine

Broader (1)

Small Inducible Cytokine A21

Papers overview

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Highly Cited
2014
Highly Cited
2014
The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes
Afferent lymph–borne dendritic cells essentially rely on the chemokine receptor CCR7 for their transition from the subcapsular… 
Highly Cited
2011
Highly Cited
2011
Dendritic cell chemotaxis in 3D under defined chemokine gradients reveals differential response to ligands CCL21 and CCL19
Dendritic cell (DC) homing to the lymphatics and positioning within the lymph node is important for adaptive immunity, and is… 
Highly Cited
2010
Highly Cited
2010
Inflammation-induced secretion of CCL21 in lymphatic endothelium is a key regulator of integrin-mediated dendritic cell transmigration.
Tissue inflammation induces rapid mobilization of antigen-charged dendritic cells (DCs), which migrate to draining lymph nodes… 
Highly Cited
2003
Highly Cited
2003
Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells
Activated insulin-specific CD8+ T cells (IS-CD8+ cells) home to the pancreas, destroy β cells, and cause rapid diabetes upon… 
Highly Cited
2003
Highly Cited
2003
Expression of B-cell-attracting chemokine 1 (CXCL13) by malignant lymphocytes and vascular endothelium in primary central nervous system lymphoma.
Primary central nervous system lymphoma (PCNSL) is a rare but often rapidly fatal form of non-Hodgkin B-cell lymphoma that arises… 
Highly Cited
2002
Highly Cited
2002
Ectopic Expression of the Murine Chemokines CCL21a and CCL21b Induces the Formation of Lymph Node-Like Structures in Pancreas, But Not Skin, of Transgenic Mice
The CC chemokine CCL21 is a potent chemoattractant for lymphocytes and dendritic cells in vitro. In the murine genome there are… 
Highly Cited
2000
Highly Cited
2000
Secondary Lymphoid Tissue Chemokine Mediates T Cell-Dependent Antitumor Responses In Vivo1
Secondary lymphoid tissue chemokine (SLC, also referred to as Exodus 2 or 6Ckine) is a recently identified high endothelial… 
Highly Cited
1997
Highly Cited
1997
Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae *
A role for sphingolipids in the yeast heat stress response has been suggested by the isolation of suppressors of mutants lacking… 
Highly Cited
1997
Highly Cited
1997
Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13*
By searching the Expressed Sequence Tag (EST) data base, we identified partial cDNA sequences potentially encoding a novel human… 
Review
1997
Review
1997
Novel lymphocyte‐specific CC chemokines and their receptors
By using a cloning method termed the signal sequence trap as well as by searching for chemokine homologous sequences in the… 
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