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Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TLDR
It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM). Expand
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
TLDR
It is shown that expression of CCR7, a chemokine receptor that controls homing to secondary lymphoid organs, divides human memory T cells into two functionally distinct subsets, which are named central memory (TCM) and effector memory (TEM). Expand
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid Organs
TLDR
Analysis of gene-targeted mice identified the chemokine receptor CCR7 as an important organizer of the primary immune response, and found that lymphocytes and dendritic cells fail to migrate into the draining lymph nodes upon activation, resulting in impaired migration of lymphocytes. Expand
A chemokine-driven positive feedback loop organizes lymphoid follicles
TLDR
It is established that B-lymphocyte chemoattractant (BLC/BCA1) and its receptor, CXCR5, are needed for B-cell homing to follicles in lymph nodes as well as in spleen, and that BLC is required for the development of most lymph nodes and Peyer's patches. Expand
Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production
Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5Expand
Cxc Chemokine Receptor 5 Expression Defines Follicular Homing T Cells with B Cell Helper Function
TLDR
These properties portray CXCR5+ T cells as a distinct memory T cell subset with B cell helper function, designated here as follicular B helper T cells (TFH). Expand
Skewed maturation of memory HIV-specific CD8 T lymphocytes
TLDR
A skewed maturation of HIV-specific memory CD8+ T cells during HIV infection is demonstrated through analysis of cell division, which demonstrates a two-step process characterized initially by a phase of proliferation largely restricted to the CCR7+CD8+ cell subsets, followed by aphase of functional maturation encompassing the C CR7-CD8- cell subset. Expand
Induced recruitment of NK cells to lymph nodes provides IFN-gamma for T(H)1 priming.
TLDR
It is shown in mice that natural killer cells, which are normally excluded from lymph nodes, are rapidly recruited in a CCR7-independent, CXCR3-dependent manner to lymph nodes on stimulation by the injection of mature DCs. Expand
Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches
TLDR
It is shown that the homing of CXCR4−/− B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. Expand
Distinct patterns and kinetics of chemokine production regulate dendritic cell function
TLDR
While CCR1 and CCR5 were down‐regulated by endogenous or exogenous chemokines, CCR7 levels gradually increased in maturing DC and showed a striking resistance to ligand‐induced down‐regulation, explaining how DC can sustain the response to SLC and ELC throughout the maturation process. Expand
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