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Identification and Molecular Characterization of Fractalkine Receptor CX3CR1, which Mediates Both Leukocyte Migration and Adhesion
Fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions. Expand
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
This work reviews this extended family of chemokine receptors and Chemokine-binding proteins at the basic, translational, and clinical levels, including an update on drug development and introduces a new nomenclature for atypical chemokin receptors with the stem ACKR (atypicalChemokine receptor). Expand
Molecular Cloning of a Novel Human CC Chemokine EBI1-ligand Chemokine That Is a Specific Functional Ligand for EBI1, CCR7*
ELC is a highly specific ligand for EBI1, which is known to be expressed in activated B and T lymphocytes and strongly up-regulated in B cells infected with Epstein-Barr virus and T cellsinfected with herpesvirus 6 or 7, and is proposed to be designated as CCR7.2 where the genes for CC chemokines are clustered. Expand
Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC*
GPR-CY4 is the specific receptor for LARC expressed selectively on lymphocytes, and LARC is a unique functional ligand for GPR-Y4, which is proposed to be designated as CCR6. Expand
The chemokine and chemokine receptor superfamilies and their molecular evolution
The genomic organization of theChemokine ligand genes and a comparison of their sequences between species shows that tandem gene duplication has taken place independently in the mouse and human lineages of some chemokine families. Expand
RANKL-induced DC-STAMP Is Essential for Osteoclastogenesis
Osteoclasts are bone-resorbing, multinucleated giant cells that are essential for bone remodeling and are formed through cell fusion of mononuclear precursor cells and DC-STAMP directly induced the expression of the osteoclast marker tartrate-resistant acid phosphatase, demonstrating for the first time that DC- STAMP has an essential role in osteoc lastogenesis. Expand
Extensive expansion and diversification of the chemokine gene family in zebrafish: Identification of a novel chemokine subfamily CX
Phylogenetic analysis and genome organization of the chemokine genes showed that successive tandem duplication events generated the CX genes from the CC subfamily, which was generated in zebrafish. Expand
Chemokine/chemokine receptor nomenclature.
A family tree of vertebrate chemokine receptors for a unified nomenclature.
A continuous gene birth and death process during the vertebrate evolution and an interesting evolutionary history of the chemokine receptor genes after the emergence in agnathans are revealed. Expand
Chemokines in immunity.
The emergence of immune chemokines has brought about a great deal of impact on the current immunological research, leading to a better understanding on the fine traffic regulation of lymphocytes and dendritic cells and likely to be important future targets for therapeutic intervention of the authors' immune responses. Expand