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Small Inducible Cytokine A21

Known as: Chemokine, CCL21, SLC Chemokine, Exodus-2 Chemokine 
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
National Institutes of Health

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11 relations
CCL21 geneIn BloodProcess of secretionRecombinant Secondary Lymphoid-Tissue Chemokine

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CCL21 protein, human

Papers overview

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Highly Cited
2001
Highly Cited
2001
Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages
A plexus of lymphatic vessels guides interstitial fluid, passenger leukocytes, and tumor cells toward regional lymph nodes… 
Highly Cited
2001
Highly Cited
2001
The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment
Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of interactions between lymphocytes and… 
Highly Cited
2000
Highly Cited
2000
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.
The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted… 
Highly Cited
2000
Highly Cited
2000
The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules
Chemokines have been hypothesized to contribute to the selectivity of lymphocyte trafficking not only as chemoattractants, but… 
Highly Cited
1999
Highly Cited
1999
Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.
Dendritic cells (DCs) emigrate to regional lymph nodes (LNs) during immune responses via afferent lymphatic channels. Secondary… 
Highly Cited
1999
Highly Cited
1999
In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines
Migration of antigen-activated CD4 T cells to B cell areas of lymphoid tissues is important for mounting T cell–dependent… 
Highly Cited
1999
Highly Cited
1999
Chemokines and the Homing of Dendritic Cells to the T Cell Areas of Lymphoid Organs
  • J. Cyster
  • Journal of Experimental Medicine
  • 1999
  • Corpus ID: 14303996
A quarter of a century ago, it was proposed that veiled cells in the lymph were antigen-bearing Langerhans' cells (LCs) en route… 
Highly Cited
1998
Highly Cited
1998
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no… 
Highly Cited
1998
Highly Cited
1998
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7
Secondary lymphoid‐tissue chemokine, SLC, also known as exodus‐2 and 6Ckine, is a novel CC chemokine with selectivity for T… 
Highly Cited
1998
Highly Cited
1998
6-C-kine (SLC), a Lymphocyte Adhesion-triggering Chemokine Expressed by High Endothelium, Is an Agonist for the MIP-3β Receptor CCR7
The β chemokine known as 6-C-kine, secondary lymphoid-tissue chemokine (SLC), TCA4, or Exodus-2 (herein referred to as 6CK/SLC… 
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