FAQ

Small Inducible Cytokine A21

Known as: Chemokine, CCL21, SLC Chemokine, Exodus-2 Chemokine 
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1997-2016
02419972016

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13 relations
CCL21 geneIn BloodProcess of secretionRecombinant Secondary Lymphoid-Tissue Chemokine
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CCL21 protein, human

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Small Inducible Cytokine A21
physiological aspects
agonists
chemical synthesis
CCL21 gene
CCL21 protein, human

Papers overview

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Highly Cited
2004
Highly Cited
2004
Dendritic cell infiltration and prognosis of early stage breast cancer.
PURPOSE Although dendritic cells (DC) and T cells can infiltrate primary breast carcinoma, it remains unclear whether the immune… (More)
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Highly Cited
2004
Highly Cited
2004
Identification of chemokines important for leukocyte recruitment to the human endometrium at the times of embryo implantation and menstruation.
Human endometrium possesses a unique immunological environment enabling implantation of the semiallogeneic embryo. Large… (More)
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Highly Cited
2000
Highly Cited
2000
The Cc Chemokine Thymus-Derived Chemotactic Agent 4 (Tca-4, Secondary Lymphoid Tissue Chemokine, 6ckine, Exodus-2) Triggers Lymphocyte Function–Associated Antigen 1–Mediated Arrest of Rolling T…
T cell homing to peripheral lymph nodes (PLNs) is defined by a multistep sequence of interactions between lymphocytes and… (More)
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Highly Cited
2000
Highly Cited
2000
The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules
Chemokines have been hypothesized to contribute to the selectivity of lymphocyte trafficking not only as chemoattractants, but… (More)
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Highly Cited
2000
Highly Cited
2000
Secondary lymphoid tissue chemokine mediates T cell-dependent antitumor responses in vivo.
Secondary lymphoid tissue chemokine (SLC, also referred to as Exodus 2 or 6Ckine) is a recently identified high endothelial… (More)
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Highly Cited
1999
Highly Cited
1999
The CC chemokine receptor-7 ligands 6Ckine and macrophage inflammatory protein-3 beta are potent chemoattractants for in vitro- and in vivo-derived dendritic cells.
Dendritic cell migration to secondary lymphoid tissues is critical for Ag presentation to T cells necessary to elicit an immune… (More)
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Highly Cited
1999
Highly Cited
1999
The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes
6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of… (More)
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Highly Cited
1998
Highly Cited
1998
The chemokine SLC is expressed in T cell areas of lymph nodes and mucosal lymphoid tissues and attracts activated T cells via CCR7.
Secondary lymphoid-tissue chemokine, SLC, also known as exodus-2 and 6Ckine, is a novel CC chemokine with selectivity for T… (More)
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Highly Cited
1998
Highly Cited
1998
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
We cloned the mouse homologue of the chemokine receptor CXCR3, which is located in mouse chromosome X. We screened a large panel… (More)
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Highly Cited
1997
Highly Cited
1997
Identification and characterization of a novel beta chemokine containing six conserved cysteines.
The chemokines are emerging as a diverse and expanding family of cytokines. In this study, we report the identification of a… (More)
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