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Small Inducible Cytokine A21

Known as: Chemokine, CCL21, SLC Chemokine, Exodus-2 Chemokine 
A CC-type chemokine with specificity for CCR7 RECEPTORS. It has activity towards DENDRITIC CELLS and T-LYMPHOCYTES.
National Institutes of Health

Related topics

Related topics

11 relations
CCL21 geneIn BloodProcess of secretionRecombinant Secondary Lymphoid-Tissue Chemokine
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CCL21 protein, human

Papers overview

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Highly Cited
2001
Highly Cited
2001
Isolation and Characterization of Dermal Lymphatic and Blood Endothelial Cells Reveal Stable and Functionally Specialized Cell Lineages
A plexus of lymphatic vessels guides interstitial fluid, passenger leukocytes, and tumor cells toward regional lymph nodes… Expand
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Highly Cited
2001
Highly Cited
2001
The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment
Lymphocyte homing to secondary lymphoid tissue is defined by a multistep sequence of interactions between lymphocytes and… Expand
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Highly Cited
2000
Highly Cited
2000
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.
The spontaneous mutant mouse strain, plt/plt, lacks the secondary lymphoid organ chemokine (SLC)-ser gene and has disrupted… Expand
Highly Cited
2000
Highly Cited
2000
The Role of Chemokines in the Microenvironmental Control of T versus B Cell Arrest in Peyer's Patch High Endothelial Venules
Chemokines have been hypothesized to contribute to the selectivity of lymphocyte trafficking not only as chemoattractants, but… Expand
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Highly Cited
1999
Highly Cited
1999
Cutting edge: secondary lymphoid-tissue chemokine (SLC) and CC chemokine receptor 7 (CCR7) participate in the emigration pathway of mature dendritic cells from the skin to regional lymph nodes.
Dendritic cells (DCs) emigrate to regional lymph nodes (LNs) during immune responses via afferent lymphatic channels. Secondary… Expand
Highly Cited
1999
Highly Cited
1999
In Vivo–Activated Cd4 T Cells Upregulate Cxc Chemokine Receptor 5 and Reprogram Their Response to Lymphoid Chemokines
Migration of antigen-activated CD4 T cells to B cell areas of lymphoid tissues is important for mounting T cell–dependent… Expand
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Highly Cited
1999
Highly Cited
1999
The CC Chemokine Receptor-7 Ligands 6Ckine and Macrophage Inflammatory Protein-3β Are Potent Chemoattractants for In Vitro- and In Vivo-Derived Dendritic Cells
Dendritic cell migration to secondary lymphoid tissues is critical for Ag presentation to T cells necessary to elicit an immune… Expand
Highly Cited
1999
Highly Cited
1999
The Reduced Expression of 6ckine in the plt Mouse Results from the Deletion of One of Two 6ckine Genes
6Ckine is an unusual chemokine capable of attracting naive T lymphocytes in vitro. It has been recently reported that lack of… Expand
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Highly Cited
1998
Highly Cited
1998
A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes.
Preferential homing of naive lymphocytes to secondary lymphoid organs is thought to involve the action of chemokines, yet no… Expand
Highly Cited
1997
Highly Cited
1997
Molecular Cloning of a Novel Human CC Chemokine Secondary Lymphoid-Tissue Chemokine That Is a Potent Chemoattractant for Lymphocytes and Mapped to Chromosome 9p13*
By searching the Expressed Sequence Tag (EST) data base, we identified partial cDNA sequences potentially encoding a novel human… Expand
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