Corpus ID: 8122706

Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.

  title={Secondary lymphoid organ chemokine reduces pulmonary tumor burden in spontaneous murine bronchoalveolar cell carcinoma.},
  author={S. Sharma and M. Stolina and L. Zhu and Y. Lin and R. Batra and M. Huang and R. Strieter and S. Dubinett},
  journal={Cancer research},
  volume={61 17},
  • S. Sharma, M. Stolina, +5 authors S. Dubinett
  • Published 2001
  • Biology, Medicine
  • Cancer research
  • The antitumor efficiency of secondary lymphoid organ chemokine (SLC), a CC chemokine that chemoattracts both dendritic cells (DCs) and T lymphocytes,was evaluated in SV40 large T-antigen transgenic mice that develop bilateral multifocal pulmonary adenocarcinomas. Injection of recombinant SLC in the axillary lymph node region led to a marked reduction in tumor burden with extensive lymphocytic and DC infiltration of the tumors and enhanced survival. SLC injection led to significant increases in… CONTINUE READING
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