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Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity
TLDR
It is shown that Stat3 is constitutively activated in diverse tumor-infiltrating immune cells, and ablating Stat3 in hematopoietic cells triggers an intrinsic immune-surveillance system that inhibits tumor growth and metastasis. Expand
Regression of established pulmonary metastases and subcutaneous tumor mediated by the systemic administration of high-dose recombinant interleukin 2
TLDR
It appears that the mechanism of the antitumor effect of recombinant IL-2 administered systemically is via the generation of LAK cells in vivo, although this hypothesis remains to be proven. Expand
Identification of human cancers deficient in antigen processing
TLDR
The findings suggest that downregulation of antigen processing may be one of the strategies used by tumors to escape immune surveillance and potential therapeutic applications include enhancing antigen processing at the level of the transcription of MHC-encoded proteasome and transporter genes. Expand
Murine dendritic cells pulsed with whole tumor lysates mediate potent antitumor immune responses in vitro and in vivo.
TLDR
In vitro and in vivo capacities of murine bone marrow-derived, cytokine-driven dendritic cells to elicit potent and specific anti-tumor responses when pulsed with whole tumor lysates are demonstrated. Expand
Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling.
TLDR
Beneficial, intratumoral immune cell priming is suggested and the possibility of immunotherapy intervention decisions based on molecular signatures that can identify the presence of tumor-localized, ectopic lymph node-like structures is raised. Expand
12-Chemokine Gene Signature Identifies Lymph Node-like Structures in Melanoma: Potential for Patient Selection for Immunotherapy?
TLDR
The 12-chemokine GES predicted the presence of unique, lymph node-like structures, containing CD20+ B cell follicles with prominent areas of CD3+ T cells, which was associated with better overall survival of the subset of melanoma patients. Expand
The dynamics of the T-cell antitumor response: chemokine-secreting dendritic cells can prime tumor-reactive T cells extranodally.
TLDR
The data demonstrate that effective T-cell priming can occur extranodally and result in measurable antitumor effects in vivo and in mice which lacked peripheral lymph nodes. Expand
Murine tumor cells transduced with the gene for tumor necrosis factor-alpha. Evidence for paracrine immune effects of tumor necrosis factor against tumors.
TLDR
TNF-producing tumor cells could function in a paracrine fashion by inhibiting the growth of unmodified, parental tumor cells implanted at the same site and this process requires the existence of intact host immunity. Expand
Design and Function of a Dendrimer-Based Therapeutic Nanodevice Targeted to Tumor Cells Through the Folate Receptor
TLDR
These results demonstrate the ability to design and produce polymer-based nanodevices for the intracellular targeting of drugs, imaging agents, and other materials. Expand
Vaccination of pediatric solid tumor patients with tumor lysate-pulsed dendritic cells can expand specific T cells and mediate tumor regression.
TLDR
It is demonstrated that it is feasible to generate large numbers of functional DC from pediatric patients even in those highly pretreated and with a large tumor burden, and the ability of the tumor lysate-pulsed DC to generate specific T-cell responses and to elicit regression of metastatic disease is demonstrated. Expand
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