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Bombesin Antagonist

Known as: BN Antagonists 
An agent that antagonizes bombesin, an endogenous neurotransmitter found in many animals, and affects smooth muscle, gastrin secretion, and renal… 
National Institutes of Health

Papers overview

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1996
1996
Bombesin may stimulate proliferation of human pancreatic cancer cells through an autocrine pathway
Bombesin is trophic to normal pancreas and acinar cell adenocarcinoma, but its effects on ductal cell tumors are undetermined… 
1996
1996
Peripheral bombesin induces gastric vagal afferent activation in rats.
Bombesin's influence on gastric vagal afferent discharge (GVAD) was studied in urethan-anesthetized rats. Vehicle and peptides… 
1993
1993
Evaluation of porfimer sodium fluorescence for measuring tissue transformation
Background. Neoplastic tissue can be detected by its increased fluorescence compared with surrounding normal tissue after the… 
Highly Cited
1992
Highly Cited
1992
Inhibition of growth of PC‐82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC‐3095 or combination of agonist [D‐Trp6]‐luteinizing hormone‐releasing hormone and…
The effects of treatment with a bombesin receptor antagonist [D‐Tpi6, Leu13Ψ(CH2NH) Leu14]BN(6–14)(RC‐3095) and the combination… 
1992
1992
Effect of [D-Phe6] bombesin (6-13) methylester, a bombesin receptor antagonist, towards bombesin-induced contractions in the guinea-pig and rat isolated urinary bladder.
1. The effect of [D-Phe6] bombesin (6-13) methylester (OMe), a newly developed potent antagonist of bombesin receptors, has been… 
Highly Cited
1990
Highly Cited
1990
Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization.
1990
1990
Receptor stimulated formation of inositol phosphates in cultures of bovine adrenal medullary cells: The effects of bradykinin, bombesin and neurotensin
Highly Cited
1989
Highly Cited
1989
Short-chain pseudopeptide bombesin receptor antagonists with enhanced binding affinities for pancreatic acinar and Swiss 3T3 cells display strong antimitotic activity.
1987
1987
Pharmacological examination of cholecystokinin (CCK-8)-induced contractile activity in the rat isolated pylorus
1985
1985
Spantide: Failure to antagonize bombesin-induced stimulation of gastrin secretion in dogs
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