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Bombesin Antagonist
Known as:
BN Antagonists
An agent that antagonizes bombesin, an endogenous neurotransmitter found in many animals, and affects smooth muscle, gastrin secretion, and renal…
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National Institutes of Health
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Papers overview
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Highly Cited
2013
Highly Cited
2013
Plasma Pharmacokinetics, Whole-Body Distribution, Metabolism, and Radiation Dosimetry of 68Ga Bombesin Antagonist BAY 86-7548 in Healthy Men
A. Roivainen
,
Esa Kähkönen
,
+12 authors
H. Minn
Journal of Nuclear Medicine
2013
Corpus ID: 23146497
This first-in-human study investigated the safety, tolerability, metabolism, pharmacokinetics, biodistribution, and radiation…
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Highly Cited
2013
Highly Cited
2013
Synthesis and characterization of a high-affinity NOTA-conjugated bombesin antagonist for GRPR-targeted tumor imaging.
Zohreh Varasteh
,
I. Velikyan
,
+7 authors
A. Orlova
Bioconjugate chemistry
2013
Corpus ID: 25441056
The gastrin-releasing peptide receptor (GRPR/BB2) is a molecular target for the visualization of prostate cancer. This work…
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Highly Cited
2010
Highly Cited
2010
Development of a potent DOTA-conjugated bombesin antagonist for targeting GRPr-positive tumours
R. Mansi
,
Xue-juan Wang
,
+6 authors
H. Maecke
European Journal of Nuclear Medicine and…
2010
Corpus ID: 11062586
PurposeRadiolabelled somatostatin-based antagonists show a higher uptake in tumour-bearing mouse models than agonists of similar…
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1995
1995
Activation of MAP kinase and translocation with HSP27 in bombesin-induced contraction of rectosigmoid smooth muscle.
H. Yamada
,
J. Strahler
,
M. Welsh
,
K. Bitar
American Journal of Physiology
1995
Corpus ID: 23465693
We have investigated whether mitogen-activated protein (MAP) kinase cascade is essential for sustained contraction of smooth…
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Highly Cited
1992
Highly Cited
1992
Inhibition of growth of PC‐82 human prostate cancer line xenografts in nude mice by bombesin antagonist RC‐3095 or combination of agonist [D‐Trp6]‐luteinizing hormone‐releasing hormone and…
S. Milovanović
,
S. Radulović
,
K. Groot
,
A. Schally
The Prostate
1992
Corpus ID: 27861576
The effects of treatment with a bombesin receptor antagonist [D‐Tpi6, Leu13Ψ(CH2NH) Leu14]BN(6–14)(RC‐3095) and the combination…
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Review
1990
Review
1990
Gastric somatostatin: a paracrine regulator of acid secretion.
G. Makhlouf
,
M. Schubert
Metabolism: Clinical and Experimental
1990
Corpus ID: 21266730
Highly Cited
1990
Highly Cited
1990
Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization.
J. Millar
,
E. Rozengurt
Journal of Biological Chemistry
1990
Corpus ID: 20968804
Highly Cited
1988
Highly Cited
1988
[D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P, a potent bombesin antagonist in murine Swiss 3T3 cells, inhibits the growth of human small cell lung cancer cells in vitro.
P. Woll
,
E. Rozengurt
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 4345220
In the search for a more potent bombesin antagonist, we found [D-Arg1,D-Phe5,D-Trp7,9,Leu11]substance P to be effective in mouse…
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Highly Cited
1986
Highly Cited
1986
Early events elicited by bombesin and structurally related peptides in quiescent Swiss 3T3 cells. I. Activation of protein kinase C and inhibition of epidermal growth factor binding
I. Zachary
,
James W. Sinnett-Srnith
,
Enrique Rozengurt
Journal of Cell Biology
1986
Corpus ID: 2674380
Addition of bombesin to quiescent cultures of Swiss 3T3 cells caused a rapid increase in the phosphorylation of an Mr 80,000…
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Highly Cited
1985
Highly Cited
1985
High-affinity receptors for peptides of the bombesin family in Swiss 3T3 cells.
I. Zachary
,
E. Rozengurt
Proceedings of the National Academy of Sciences…
1985
Corpus ID: 28849441
Gastrin-releasing peptide (GRP) labeled with 125I at tyrosine-15 (125I-GRP) binds to intact quiescent Swiss 3T3 cells in a…
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