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Human distribution and release of a putative new gut hormone, peptide YY.
Neuropeptide Y distribution in the rat brain.
Column chromatography of brain extracts and double immunostaining experiments indicate that neuropeptide Y is the endogenous brain peptide responsible for Immunostaining of pancreatic polypeptides-like immunoreactivity in the mammalian brain.
Effects of peptide YY (PYY) on mouth to caecum intestinal transit time and on the rate of gastric emptying in healthy volunteers.
The infusion of PYY shows a dose related inhibition of mouth to caecum intestinal transit time and of the rate of gastric emptying and suggests this novel hormonal peptide to be of importance in gastrointestinal physiology.
Frondoside A Suppressive Effects on Lung Cancer Survival, Tumor Growth, Angiogenesis, Invasion, and Metastasis
Frondoside A is identified as a promising novel therapeutic agent for lung cancer and enhanced the inhibition of lung tumor growth induced by the chemotherapeutic agent cisplatin.
Deoxycholate is an important releaser of peptide YY and enteroglucagon from the human colon.
It is suggested that bile salts may play an important part in the control of colonic endocrine function and may explain the increased circulating concentrations of Colonic regulatory peptides that are seen in malabsorption states and after small bowel resection in humans.
Neuropeptide Y distribution in human brain
NPY, a newly discovered peptide with potent biological activity, seems to be among the most abundant of human neuropeptides, being particularly concentrated in the basal ganglia, amygdala and nucleus accum-bens.
Peptide YY abnormalities in gastrointestinal diseases.
The effect of the mammalian neuropeptide, gastrin-releasing peptide (GRP), on gastrointestinal and pancreatic hormone secretion in man.
Its specific location in nerve fibres in the proximal gut and pancreas and its selective effect on gastroenteropancreatic peptides may favour its role as a physiological regulatory neuropeptide.
Rectal taurocholate increases L cell and insulin secretion, and decreases blood glucose and food intake in obese type 2 diabetic volunteers
Therapies that increase bile salts (or their mimics in the distal bowel may be valuable in the treatment of type 2 diabetes and obesity.
The distribution and origin of a novel brain peptide, neuropeptide Y, in the spinal cord of several mammals
- S. Gibson, J. Polak, J. Allen, T. Adrian, J. Kelly, S. Bloom
- BiologyThe Journal of comparative neurology
- 20 July 1984
Analysis of spinal cord extracts by reverse phase high performance liquid chromatography [HPLC] demonstrated that NPY‐immunoreactive material elutes in the position of pure NPY standard.