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Cyclophosphamide cystitis in rats: involvement of capsaicin-sensitive primary afferents.
Analysis of factors involved in determining urinary bladder voiding cycle in urethan-anesthetized rats.
The mechanism(s) involved in determining the voiding cycle of the rat urinary bladder have been investigated in urethan-anesthetized animals and the reflex (hexamethonium sensitive) mechanism responsible for the generation of IPHFO is more developed in male than female rats.
Tachykinins and calcitonin gene-related peptide as co-transmitters in local motor responses produced by sensory nerve activation in the guinea-pig isolated renal pelvis
Involvement of 5-hydroxytryptamine1A receptors in the modulation of micturition reflexes in the anesthetized rat.
- A. Lecci, S. Giuliani, P. Santicioli, C. Maggi
- BiologyThe Journal of pharmacology and experimental…
- 1 July 1992
Intravenous administration of the selective 5-hydroxytryptamine (5-HT)1A receptor agonist 8-hydroxy-2-(di-N-propylaminotetralin (8-OH-DPAT) and of a low doses of buspirone elicited the supraspinal…
Hydrogen sulfide (H2S) stimulates capsaicin‐sensitive primary afferent neurons in the rat urinary bladder
Results provide pharmacological evidence that H2S stimulates capsaicin‐sensitive primary afferent nerve terminals, from which tachykinins are released to produce the observed contraction by activating NK1 and NK2 receptors.
Effect of nociceptin on heart rate and blood pressure in anaesthetized rats.
Peripheral actions of tachykinins
- A. Lecci, S. Giuliani, M. Tramontana, F. Carini, C. Maggi
- Biology, MedicineNeuropeptides
- 1 October 2000
Preclinical evidence obtained through the use of selective tachykinin receptor antagonists indicates that endogenous tachyKinins are involved in augmented smooth muscle contraction, vasodilatation, chemotaxis and activation of immune cells, mucus secretion, water absorption/secretion.
Urantide: an ultrapotent urotensin II antagonist peptide in the rat aorta
- R. Patacchini, P. Santicioli, C. Maggi
- Biology, ChemistryBritish journal of pharmacology
- 1 December 2003
To the knowledge, urantide is the most potent UT receptor antagonist so far described, and might represent a useful tool for exploring the (patho)physiological role of hU‐II in the mammalian cardiovascular system.
Pharmacological investigation of hydrogen sulfide (H2S) contractile activity in rat detrusor muscle.
Pharmacological evaluation of the role of cyclooxygenase isoenzymes on the micturition reflex following experimental cystitis in rats
Results indicate that COX‐1 may be involved in modulating the threshold for activating the micturition reflex in the normal rats and demonstrates that inhibition of COX-2 prevents or reverses the urodynamic changes associated with bladder inflammation induced either by surgery, LPS or CYP treatments.