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Bax protein

Known as: BAX Isoform Alpha, bcl 2 Associated X Protein, BCL2-Associated X Protein 
A member of the Bcl-2 protein family and homologous partner of C-BCL-2 PROTO-ONCOGENE PROTEIN. It regulates the release of CYTOCHROME C and APOPTOSIS… 
National Institutes of Health

Related topics

Related topics

24 relations
ApoptosisApoptosis PromoterBAX geneBH1 Domain

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
PUMA and Bax-induced Autophagy Contributes to Apoptosis
The p53-inducible BH3-only protein PUMA is a key mediator of p53-dependent apoptosis, and PUMA has been shown to function by… 
Highly Cited
2006
Highly Cited
2006
Complete Dissociation of Motor Neuron Death from Motor Dysfunction by Bax Deletion in a Mouse Model of ALS
The death of cranial and spinal motoneurons (MNs) is believed to be an essential component of the pathogenesis of amyotrophic… 
Highly Cited
2002
Highly Cited
2002
TRAIL-induced apoptosis requires Bax-dependent mitochondrial release of Smac/DIABLO.
Recent reports suggest that a cross-talk exists between apoptosis pathways mediated by mitochondria and cell death receptors. In… 
Highly Cited
2001
Highly Cited
2001
Induction of BIM, a Proapoptotic BH3-Only BCL-2 Family Member, Is Critical for Neuronal Apoptosis
Highly Cited
2000
Highly Cited
2000
Intravenous Brain-Derived Neurotrophic Factor Reduces Infarct Size and Counterregulates Bax and Bcl-2 Expression After Temporary Focal Cerebral Ischemia
Background and Purpose Pretreatment with intraventricular brain-derived neurotrophic factor (BDNF) reduces ischemic damage after… 
Highly Cited
1998
Highly Cited
1998
Widespread Elimination of Naturally Occurring Neuronal Death inBax-Deficient Mice
The proapoptotic molecule BAX is required for death of sympathetic and motor neurons in the setting of trophic factor deprivation… 
Highly Cited
1998
Highly Cited
1998
Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cell.
Physical forces activate apoptosis and gene expression, but the mechanism is unknown. For this purpose, adult myocytes were… 
Review
1996
Review
1996
The cell-death machine
Highly Cited
1996
Highly Cited
1996
The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-inducible and death-promoting Bax protein.
The E1B 19K protein is a potent apoptosis inhibitor and the putative adenovirus Bcl-2 homolog. To investigate the mechanism of… 
Highly Cited
1995
Highly Cited
1995
Upregulation of bax protein levels in neurons following cerebral ischemia
The patterns of expression of the bcl-2, bax, and bci-X genes were examined immunohistochemically in neurons of the adult rat… 
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