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BAX gene

Known as: BCL2-ASSOCIATED X PROTEIN, BAX, BCL2-Associated X Protein Gene 
This gene is involved in the regulation of apoptosis by binding p53 protein, which accelerates this mechanism of cell death.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisBax proteinColorectal CarcinomaMalignant neoplasm of large intestine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
Direct and selective small-molecule activation of proapoptotic BAX.
BCL-2 family proteins are key regulators of the apoptotic pathway. Antiapoptotic members sequester the BCL-2 homology 3 (BH3… 
Highly Cited
2011
Highly Cited
2011
Bax dimerizes via a symmetric BH3:groove interface during apoptosis
During apoptotic cell death, Bax and Bak change conformation and homo-oligomerize to permeabilize mitochondria. We recently… 
Highly Cited
2009
Highly Cited
2009
The role of BH3-only protein Bim extends beyond inhibiting Bcl-2–like prosurvival proteins
Proteins of the Bcl-2 family are critical regulators of apoptosis, but how its BH3-only members activate the essential effectors… 
Highly Cited
2004
Highly Cited
2004
hsp70-DnaJ chaperone pair prevents nitric oxide- and CHOP-induced apoptosis by inhibiting translocation of Bax to mitochondria
AbstractWe reported that the endoplasmic reticulum (ER) stress pathway involving CHOP, a member of the C/EBP transcription factor… 
Highly Cited
2002
Highly Cited
2002
Resistance of colon cancer cells to long‐term 5‐fluorouracil exposure is correlated to the relative level of Bcl‐2 and Bcl‐XL in addition to Bax and p53 status
Defects in apoptosis have been implicated in chemoresistance of colon cancer cells. We report here the ability to resist to 5… 
Highly Cited
2000
Highly Cited
2000
Apoptosis Control in Syncytia Induced by the HIV Type 1–Envelope Glycoprotein Complex
Syncytia arising from the fusion of cells expressing a lymphotropic HIV type 1–encoded envelope glycoprotein complex (Env) with… 
Highly Cited
2000
Highly Cited
2000
Relapse in childhood acute lymphoblastic leukemia is associated with a decrease of the Bax/Bcl-2 ratio and loss of spontaneous caspase-3 processing in vivo
Dysfunction of the p53/Bax/caspase-3 apoptosis signaling pathway has been shown to play a role in tumorigenesis and tumor… 
Highly Cited
1999
Highly Cited
1999
Bcl‐xL regulates apoptosis by heterodimerization‐dependent and ‐independent mechanisms
A hydrophobic cleft formed by the BH1, BH2 and BH3 domains of Bcl‐xL is responsible for interactions between Bcl‐xL and BH3… 
Highly Cited
1997
Highly Cited
1997
Lack of butyrate is associated with induction of Bax and subsequent apoptosis in the proximal colon of guinea pig.
BACKGROUND & AIMS Butyrate stimulates proliferation and suppresses differentiation in normal colonic epithelial cells. Because… 
Highly Cited
1996
Highly Cited
1996
Bcl‐2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.
Human Bcl‐2 is located in multiple intracellular membranes when expressed in MDCK and Rat‐1/myc cells. We restricted expression… 
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