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BAX gene

Known as: BCL2-ASSOCIATED X PROTEIN, BAX, BCL2-Associated X Protein Gene 
This gene is involved in the regulation of apoptosis by binding p53 protein, which accelerates this mechanism of cell death.
National Institutes of Health

Related topics

Related topics

6 relations
ApoptosisBax proteinColorectal CarcinomaMalignant neoplasm of large intestine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2007
Highly Cited
2007
Single-nucleotide polymorphisms at the TP53-binding or responsive promoter regions of BAX and BCL2 genes and risk of squamous cell carcinoma of the head and neck.
Tumor protein 53 (TP53), a transcriptional factor, induces expression of the B-cell lymphoma 2-associated X protein (BAX) gene by… 
Highly Cited
2006
Highly Cited
2006
Identification of mouse sphingomyelin synthase 1 as a suppressor of Bax-mediated cell death in yeast.
We have identified mouse sphingomyelin synthase 1 as a novel suppressor of the growth inhibitory effect of heterologously… 
Highly Cited
2002
Highly Cited
2002
Bax-induced cell death in yeast depends on mitochondrial lipid oxidation.
The oxidant function of pro-apoptotic protein Bax was investigated through heterologous expression in yeast. Direct measurements… 
Highly Cited
2002
Highly Cited
2002
Soybean ascorbate peroxidase suppresses Bax-induced apoptosis in yeast by inhibiting oxygen radical generation.
Bax, a mammalian proapoptotic member of the Bcl-2 family, can induce cell death when expressed in yeast or plant cells. To… 
Highly Cited
2001
Highly Cited
2001
Expression and Redistribution of Cellular Bad, Bax, and Bcl-xL Protein Is Associated with VCD-Induced Ovotoxicity in Rats1
Abstract Previous studies have shown that 4-vinylcyclohexene diepoxide (VCD)-induced ovotoxicity in rats is likely caused by… 
Highly Cited
2000
Highly Cited
2000
Transfection with mutant p53 gene inhibits heat-induced apoptosis in a head and neck cell line of human squamous cell carcinoma.
Highly Cited
1999
Highly Cited
1999
Analysis of the p53/BAX pathway in colorectal cancer: low BAX is a negative prognostic factor in patients with resected liver metastases.
PURPOSE To determine the prognostic value of the central downstream apoptosis effector BAX in relation to its upstream regulator… 
Highly Cited
1999
Highly Cited
1999
Comparison of the effects of bax‐expression in yeast under fermentative and respiratory conditions: investigation of the role of adenine nucleotides carrier and cytochrome c
Highly Cited
1997
Highly Cited
1997
The BH3 domain of Bax is sufficient for interaction of Bax with itself and with other family members and it is required for induction of apoptosis.
bax is an apoptosis-inducing member of the bcl-2 multigene family. We have studied interactions of human Bax with itself, and… 
Highly Cited
1997
Highly Cited
1997
Induction of T cell clonal anergy results in resistance, whereas CD28-mediated costimulation primes for susceptibility to Fas- and Bax-mediated programmed cell death.
Since TCR-mediated stimulation induces T cells to become sensitive to Fas-mediated activation-induced cell death (Fas-AICD), we… 
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