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n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
Evidence is provided that these n-3 PUFAs are able to inhibit VEGF expression in colon cancer cells and suggest that one possible mechanism involved may be the negative regulation of the COX-2/PGE(2) pathway. Expand
DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism.
The data herein presented demonstrate the oxidative effect of Mancozeb and suggest that its prooxidant action may be involved in the proapoptotic effect exerted by this compound in rat cells. Expand
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model.
When the conjugated keto-carotenoids are added to rat liver microsomes undergoing radical-initiated lipid peroxidation under air, they are as effective as alpha-tocopherol in inhibiting this process. Expand
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
The ability of lycopene in inhibiting HMG-CoA reductase expression and cell growth and in inactivating Ras was also found in prostate PC-3, colon HCT-116 and HT-29 and lung BEN cancer cells, providing a novel mechanistic insight into the growth-inhibitory effects of ly Copene. Expand
Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression.
Whether lycopene is able to counteract oxysterol-induced proinflammatory cytokines cascade in human macrophages is investigated, limiting the formation of atherosclerotic plaque and new information is brought on the anti-atherogenic properties of lycopenes, and on its mechanisms of action in atherosclerosis prevention. Expand
Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells.
The growth-inhibitory effects of the astaxanthin-rich Haematococcus pluvialis were studied in HCT-116 colon cancer cells and it is suggested that H. pluvials may protect from colon cancer. Expand
Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies.
Focusing on cell culture studies, this review summarizes the experimental evidence for a role of lycopene in the different phases of atherosclerotic process. Expand
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
In this experimental model, apoptosis is apparently independent of the inhibition of fatty acid synthesis and of malonyl-CoA cytotoxicity, and it was observed that apoptosis induced by the alpha-linolenic acid-enriched diet correlated with a decrease in arachidonate content in hepatoma cells and decreased cyclooxygenase-2 expression. Expand
β-Carotene and α-tocopherol are synergistic antioxidants
Abstract The possibility of a cooperative interaction between fat-soluble antioxidants is examined in a membrane model. A combination of β-carotene and α-tocopherol results in an inhibition of lipidExpand
Antioxidant effects of carotenoids in vivo and in vitro: an overview.
This chapter evaluates the available evidence for this explanation of in vivo biological activity of carotenoids and describes their role as biological antioxidants in radical-initiated processes, both in vitro and in vivo. Expand