DNA damage and apoptosis induction by the pesticide Mancozeb in rat cells: involvement of the oxidative mechanism.
- G. Calviello, E. Piccioni, P. Palozza
- BiologyToxicology and Applied Pharmacology
- 1 March 2006
n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway.
- G. Calviello, F. Di Nicuolo, P. Palozza
- BiologyCarcinogenesis
- 1 December 2004
Evidence is provided that these n-3 PUFAs are able to inhibit VEGF expression in colon cancer cells and suggest that one possible mechanism involved may be the negative regulation of the COX-2/PGE(2) pathway.
Lycopene induces cell growth inhibition by altering mevalonate pathway and Ras signaling in cancer cell lines.
- P. Palozza, M. Colangelo, F. Ranelletti
- Biology, ChemistryCarcinogenesis
- 1 October 2010
The ability of lycopene in inhibiting HMG-CoA reductase expression and cell growth and in inactivating Ras was also found in prostate PC-3, colon HCT-116 and HT-29 and lung BEN cancer cells, providing a novel mechanistic insight into the growth-inhibitory effects of ly Copene.
Astaxanthin and canthaxanthin are potent antioxidants in a membrane model.
- P. Palozza, N. Krinsky
- Biology, ChemistryArchives of Biochemistry and Biophysics
- 1 September 1992
Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells.
- P. Palozza, C. Torelli, N. Picci
- BiologyCancer Letters
- 28 September 2009
Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages.
- P. Palozza, R. Simone, F. Ranelletti
- Biology, ChemistryJournal of Nutritional Biochemistry
- 2010
Lycopene prevention of oxysterol-induced proinflammatory cytokine cascade in human macrophages: inhibition of NF-κB nuclear binding and increase in PPARγ expression.
- P. Palozza, R. Simone, F. Ranelletti
- Biology, ChemistryJournal of Nutritional Biochemistry
- 1 March 2011
Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies.
- P. Palozza, N. Parrone, R. Simone, A. Catalano
- BiologyArchives of Biochemistry and Biophysics
- 1 December 2010
Antioxidant effects of carotenoids in vivo and in vitro: an overview.
- P. Palozza, N. Krinsky
- Biology, ChemistryMethods in Enzymology
- 1992
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
- A. Vecchini, V. Ceccarelli, P. di Nardo
- BiologyJournal of Lipid Research
- 1 February 2004
In this experimental model, apoptosis is apparently independent of the inhibition of fatty acid synthesis and of malonyl-CoA cytotoxicity, and it was observed that apoptosis induced by the alpha-linolenic acid-enriched diet correlated with a decrease in arachidonate content in hepatoma cells and decreased cyclooxygenase-2 expression.
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