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BH3 Domain
The alpha-helical BH3 domain (9 amino acids) represents a minimal death domain and is essential for the activity of pro-apoptotic members of the bcl…
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National Institutes of Health
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Related topics
Related topics
12 relations
BCL-XL Protein
BCL-Xs protein
BCL2-Interacting Killer
BID protein
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Targeting Bcl-2-IP3 receptor interaction to treat cancer: A novel approach inspired by nearly a century treating cancer with adrenal corticosteroid hormones.
C. Distelhorst
Biochimica et biophysica acta. Molecular cell…
2018
Corpus ID: 51726474
2012
2012
The MUC1-C Oncoprotein Binds to the BH3 Domain of the Pro-apoptotic BAX Protein and Blocks BAX Function*
Rehan Ahmad
,
Maroof Alam
,
H. Rajabi
,
D. Kufe
Journal of Biological Chemistry
2012
Corpus ID: 4960029
Background: The MUC1-C oncoprotein attenuates activation of the intrinsic apoptotic pathway by mechanisms that are not understood…
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Highly Cited
2005
Highly Cited
2005
Neurons Exclusively Express N-Bak, a BH3 Domain-only Bak Isoform That Promotes Neuronal Apoptosis*
T. Uo
,
Y. Kinoshita
,
R. Morrison
Journal of Biological Chemistry
2005
Corpus ID: 10183629
Bak is generally recognized as a multidomain, pro-apoptotic member of the Bcl-2 family. Bak and Bax are functionally redundant in…
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2003
2003
Particle assembly incorporating a VP22-BH3 fusion protein, facilitating intracellular delivery, regulated release, and apoptosis.
Neil Douglas Brewis
,
Anne Phelan
,
Nadia Michelle Normand
,
E. Choolun
,
Peter O'Hare
Molecular Therapy
2003
Corpus ID: 8661502
Highly Cited
2002
Highly Cited
2002
Bcl-XL Protects BimEL-induced Bax Conformational Change and Cytochrome c Release Independent of Interacting with Bax or BimEL*
H. Yamaguchi
,
Hong-Gang Wang
Journal of Biological Chemistry
2002
Corpus ID: 20231920
The Bcl-2 homology (BH) 3-only pro-apoptotic Bcl-2 family protein Bim plays an essential role in the mitochondrial pathway of…
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2001
2001
Bcl-xS can form homodimers and heterodimers and its apoptotic activity requires localization of Bcl-xS to the mitochondria and its BH3 and loop domains
L. Lindenboim
,
C. Borner
,
R. Stein
Cell Death and Differentiation
2001
Corpus ID: 19450792
Proteins of the Bcl-2 family regulate apoptosis, some antagonizing cell death and others, such as Bcl-xS, promoting it. We…
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2001
2001
Bid regulation of neuronal apoptosis.
J. Leonard
,
C. D'Sa
,
B. R. Cahn
,
S. Korsmeyer
,
K. Roth
Brain research. Developmental brain research
2001
Corpus ID: 347734
Highly Cited
2001
Highly Cited
2001
Induction of apoptosis in prostate carcinoma cells by BH3 peptides which inhibit Bak/Bcl-2 interactions
N. Finnegan
,
James F Curtin
,
G. Prévost
,
B. Morgan
,
T. Cotter
British Journal of Cancer
2001
Corpus ID: 12309937
Interactions between proteins of the Bcl-2 family play an important role in the regulation of apoptosis. Anti-apoptotic family…
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2000
2000
Functional identification of the apoptosis effector BH3 domain in cellular protein BNIP1
M. Yasuda
,
G. Chinnadurai
Oncogene
2000
Corpus ID: 896630
BCL-2 family proteins play a central role in apoptosis regulation in mammals and in C. elegans. Mammalian cellular and viral anti…
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Review
1999
Review
1999
Programmed cell death in the nematode C. elegans.
M. Hengartner
Recent Progress in Hormone Research
1999
Corpus ID: 24815803
Programmed cell death is a common feature during animal development. In the nematode C. elegans, more than 12 genes have been…
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