BH3 Domain

The alpha-helical BH3 domain (9 amino acids) represents a minimal death domain and is essential for the activity of pro-apoptotic members of the bcl… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2001-2016
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2017
2017
Endostatin (ES) is an antiangiogenic protein that exhibits antitumor activity in animal models. However, the activity observed in… (More)
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2016
2016
BECN1/Beclin 1 has a critical role in the early stages of autophagosome formation. Recently, structures of its central and C… (More)
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2016
2016
Beclin 1 is a 450 amino acid protein that plays critical roles in the early stages of autophagosome formation. We recently… (More)
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2013
2013
Prodigiosin and obatoclax, members of the prodiginines family, are small molecules with anti-cancer properties that are currently… (More)
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2013
2013
The present studies focused on defining the mechanisms by which anoikis-resistant (AR) mammary carcinoma cells can be reverted to… (More)
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2013
2013
We have used computational methods to improve the affinity of a foldamer ligand for its target protein. The effort began with a… (More)
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2012
2012
Recently we reported that the BH3-only proteins Bim and Noxa bind tightly but transiently to the BH3-binding groove of Bak to… (More)
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2012
2012
The BH3 domain of Bcl-2 proteins was regarded as indispensable for apoptosis induction and for mutual regulation of family… (More)
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2010
2010
Apoptosis, or programmed cell death, forms an important part of the cellular regulation machinery. The Bcl-2 protein family… (More)
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2001
2001
Kaposi’s sarcoma (KS) is the most common tumor affecting AIDS patients with over 20% of these patients afflicted by this disease… (More)
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