BCL2-Interacting Killer

Known as: Apoptosis-Inducing NBK, Bcl-2-Interacting Killer, BP4 
Bcl-2-interacting killer (160 aa, ~18 kDa) is encoded by the human BIK gene. This protein plays a role in apoptosis.
National Institutes of Health

Papers overview

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2013
2013
BINDING PROTEIN (BiP) is a major chaperone in the endoplasmic reticulum (ER) lumen, and this study shows that BiP binds to the C… (More)
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Highly Cited
2010
Highly Cited
2010
In addition to mitochondria, BCL-2 is located at the endoplasmic reticulum (ER) where it is a constituent of several distinct… (More)
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2009
Highly Cited
2009
BACKGROUND Recurrent 15q13.3 microdeletions were recently identified with identical proximal (BP4) and distal (BP5) breakpoints… (More)
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2008
2008
The BH3-only protein BIK normally induces apoptotic cell death. Here, we have investigated the role of BCL-2 in BIK-induced cell… (More)
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Highly Cited
2007
Highly Cited
2007
Ribonucleases, antibiotics, bacterial toxins, and viruses inhibit protein synthesis, which results in apoptosis in mammalian… (More)
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2006
2006
DNA methylation and histone acetylation are main epigenetic events regulating gene expression, serving as anticancer drug targets… (More)
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2005
Highly Cited
2005
Proteasome inhibitors have emerged as promising anticancer therapeutic agents. Bortezomib (PS-341), a specific proteasome… (More)
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Highly Cited
2004
Highly Cited
2004
The BH3-only members of the Bcl-2 protein family are essential for initiation of programmed cell death and stress-induced… (More)
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2004
Highly Cited
2004
Evidence has been accumulating that some estrogen-dependent human breast cancers require estrogen for not only proliferation but… (More)
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2000
2000
Neutrophils possess a very short lifespan, dying by apoptosis. HL-60 cells undergo apoptosis after neutrophil differentiation… (More)
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