BCL-XL Protein

Known as: Bcl2-Related Protein, Long Isoform, bcl Xlong Protein, BCL2-Like 1, Long Isoform 
Bcl-XL is an anti-apoptotic protein that is the long isoform of Bcl-X protein. Bcl-XL localizes to the outer mitochondrial membrane and is… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Since apoptosis is impaired in malignant cells overexpressing prosurvival Bcl-2 proteins, drugs mimicking their natural… (More)
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Highly Cited
2005
Highly Cited
2005
Commitment of cells to apoptosis is governed largely by the interaction between members of the Bcl-2 protein family. Its three… (More)
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Highly Cited
2005
Highly Cited
2005
Apoptosis is initiated when Bcl-2 and its prosurvival relatives are engaged by proapoptotic BH3-only proteins via interaction of… (More)
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Highly Cited
1999
Highly Cited
1999
During transduction of an apoptotic (death) signal into the cell, there is an alteration in the permeability of the membranes of… (More)
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Highly Cited
1999
Highly Cited
1999
"BH3 domain only" members of the BCL-2 family including the pro-apoptotic molecule BID represent candidates to connect with… (More)
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Highly Cited
1997
Highly Cited
1997
Mitochondrial physiology is disrupted in either apoptosis or necrosis. Here, we report that a wide variety of apoptotic and… (More)
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Highly Cited
1996
Highly Cited
1996
Extracellular survival factors alter a cell's susceptibility to apoptosis, often through posttranslational mechanisms. However… (More)
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Highly Cited
1996
Highly Cited
1996
THE Bcl-2 family of proteins regulate programmed cell death by an unknown mechanism1. Here we describe the crystal and solution… (More)
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Highly Cited
1995
Highly Cited
1995
To extend the mammalian cell death pathway, we screened for further Bcl-2 interacting proteins. Both yeast two-hybrid screening… (More)
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Highly Cited
1993
Highly Cited
1993
We report the isolation of bcl-x, a bcl-2-related gene that can function as a bcl-2-independent regulator of programmed cell… (More)
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