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The biochemistry of apoptosis
Apoptosis — the regulated destruction of a cell — is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating itsExpand
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Genetic control of programmed cell death in the Caenorhabditis elegans hermaphrodite germline.
Development of the nematode Caenorhabditis elegans is highly reproducible and the fate of every somatic cell has been reported. We describe here a previously uncharacterized cell fate in C. elegans:Expand
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Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012
In 2009, the Nomenclature Committee on Cell Death (NCCD) proposed a set of recommendations for the definition of distinct cell death morphologies and for the appropriate use of cell death-relatedExpand
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Caenorhabditis elegans gene ced-9 protects cells from programmed cell death
The gene ced-9 of the nematode Caenorhabditis elegansacts to protect cells from programmed cell death. A mutation that abnormally activatesced-9 prevents the cell deaths that occur during normal C.Expand
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A conserved checkpoint pathway mediates DNA damage--induced apoptosis and cell cycle arrest in C. elegans.
To maintain genomic stability following DNA damage, multicellular organisms activate checkpoints that induce cell cycle arrest or apoptosis. Here we show that genotoxic stress blocks cellExpand
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Microtubule-associated protein 1 light chain 3 alpha (LC3)-associated phagocytosis is required for the efficient clearance of dead cells
The recognition and clearance of dead cells is a process that must occur efficiently to prevent an autoimmune or inflammatory response. Recently, a process was identified wherein the autophagyExpand
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Caenorhabditis elegans HUS-1 Is a DNA Damage Checkpoint Protein Required for Genome Stability and EGL-1-Mediated Apoptosis
BACKGROUND The inability to efficiently repair DNA damage or remove cells with severely damaged genomes has been linked to several human cancers. Studies in yeasts and mammals have identified severalExpand
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Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009
Different types of cell death are often defined by morphological criteria, without a clear reference to precise biochemical mechanisms. The Nomenclature Committee on Cell Death (NCCD) proposesExpand
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Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
Cells exposed to extreme physicochemical or mechanical stimuli die in an uncontrollable manner, as a result of their immediate structural breakdown. Such an unavoidable variant of cellular demise isExpand
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C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2
The activity of the C. elegans gene ced-9 is required to protect cells that normally survive from undergoing programmed cell death. Here we describe the cloning and molecular characterization of thisExpand
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