Azathioprine

Known as: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine, Azathioprine [Chemical/Ingredient] 
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its… (More)

Topic mentions per year

Topic mentions per year

1951-2018
020040060019512017

Papers overview

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Review
2016
Review
2016
The crucial issue for a better pregnancy outcome in women with autoimmune rheumatic diseases is appropriate planning, with… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND Maintenance therapy, often with azathioprine or mycophenolate mofetil, is required to consolidate remission and… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease… (More)
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Highly Cited
2009
Highly Cited
2009
To the Editor: In their prospective, open-label trial, Pagnoux et al. (Dec. 25 issue)1 compared azathioprine (at a dose of 2 mg… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND AND AIMS There are limited evidence based data concerning the use of azathioprine in ulcerative colitis. We aimed to… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND Inflammatory bowel disease (IBD) is commonly treated with immunomodulators such as azathioprine and 6-mercaptopurine… (More)
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Highly Cited
2003
Highly Cited
2003
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that are used in organ transplantation and… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Acute rejection episodes after renal transplantation are an important clinical challenge, despite use of multidrug… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND & AIMS Myelosuppression in patients with Crohn's disease (CD) treated with azathioprine has been attributed to low… (More)
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Highly Cited
1995
Highly Cited
1995
While immunosuppressive agents are used widely in the management of Crohn's disease, their efficacy has not been well established… (More)
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