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Azathioprine

Known as: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine, Azathioprine [Chemical/Ingredient] 
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its… 
National Institutes of Health

Related topics

Related topics

33 relations

Broader (5)

AntimetabolitesAntimetabolites, AntineoplasticAntirheumatic AgentsImmunosuppressive Agents
Azathioprine 50 MG Oral Tablet [Imuran]Azathioprine:MCnc:Pt:Ser/Plas:QnAzathioprine:PrThr:Pt:Ser/Plas:OrdCrohn Disease

Narrower (3)

ImuranImurelthiamiprine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Highly stable and porous cross-linked polymers for efficient photocatalysis.
Porous cross-linked polymers (PCPs) with phosphorescent [Ru(bpy)(3)](2+) and [Ir(ppy)(2)(bpy)](+) building blocks were obtained… 
Highly Cited
2010
Highly Cited
2010
Visible-light photoredox catalysis: aza-Henry reactions via C-H functionalization.
We report the application of visible-light photoredox catalysis for the formation of C-C bonds between tertiary N-arylamines and… 
Highly Cited
2003
Highly Cited
2003
Randomized, double-blind comparison of 4 mg/kg versus 2 mg/kg intravenous cyclosporine in severe ulcerative colitis.
Review
2003
Review
2003
Tacrolimus: a further update of its use in the management of organ transplantation.
UNLABELLED Extensive clinical use has confirmed that tacrolimus (Prograf) is a key option for immunosuppression after… 
Highly Cited
2003
Highly Cited
2003
Azathioprine: old drug, new actions.
A knowledge of the biochemical loci of action of 6-MP in the inhibition of nucleic acid synthesis is not sufficient to explain… 
Highly Cited
2002
Highly Cited
2002
Rare-earth metal triflates in organic synthesis.
2.1.8. Michael Reaction 2245 2.1.9. Others 2247 2.2. Cyclization Reactions 2248 2.2.1. Carbon Diels−Alder Reactions 2248 2.2.2… 
Highly Cited
1998
Highly Cited
1998
Thiopurine Methyltransferase Genotype Predicts Therapy-Limiting Severe Toxicity from Azathioprine
Azathioprine has demonstrated disease-modifying activity in rheumatic disease and is an effective therapy for inflammatory bowel… 
Highly Cited
1995
Highly Cited
1995
A controlled double blind study of azathioprine in the management of Crohn's disease.
While immunosuppressive agents are used widely in the management of Crohn's disease, their efficacy has not been well established… 
Review
1993
Review
1993
Bone marrow toxicity caused by azathioprine in inflammatory bowel disease: 27 years of experience.
Myelosuppression is an important and potentially lethal complication of azathioprine treatment. The blood count has been reviewed… 
Highly Cited
1976
Highly Cited
1976
Crohn's Disease
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