Skip to search formSkip to main contentSkip to account menu

Azathioprine

Known as: 6-[(1-Methyl-4-nitro-1H-imidazol-5-yl)thio]-1H-purine, 6-(1'-Methyl-4'-nitro-5'-imidazolyl)-mercaptopurine, Azathioprine [Chemical/Ingredient] 
A purine analogue with cytotoxic and immunosuppressive activity. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
BACKGROUND The combination of cyclophosphamide and glucocorticoids leads to remission in most patients with antineutrophil… 
Highly Cited
2012
Highly Cited
2012
BACKGROUND A combination of prednisone, azathioprine, and N-acetylcysteine (NAC) has been widely used as a treatment for… 
Highly Cited
2010
Highly Cited
2010
BACKGROUND The comparative efficacy and safety of infliximab and azathioprine therapy alone or in combination for Crohn's disease… 
Highly Cited
2008
Highly Cited
2008
BACKGROUND Current standard therapy for Wegener's granulomatosis and microscopic polyangiitis combines corticosteroids and… 
Highly Cited
2005
Highly Cited
2005
Oxidative stress and mutagenic DNA lesions formed by reactive oxygen species (ROS) are linked to human malignancy. Clinical… 
Highly Cited
2005
Highly Cited
2005
Background: Inflammatory bowel disease (IBD) is commonly treated with immunomodulators such as azathioprine and 6-mercaptopurine… 
Highly Cited
2003
Highly Cited
2003
Azathioprine and its metabolite 6-mercaptopurine (6-MP) are immunosuppressive drugs that are used in organ transplantation and… 
Review
2002
Review
2002
Chemotherapeutics are the most effective treatment for metastatic tumours. However, the ability of cancer cells to become… 
Highly Cited
2002
Highly Cited
2002
PURPOSE Patients with high-risk myelodysplastic syndrome (MDS) have high mortality from bone marrow failure or transformation to… 
Review
1995
Review
1995
The antimetabolite agents azathioprine and 6-mercaptopurine are purine analogs that interfere with nucleic acid metabolism and…