Tramadol: a review of its use in perioperative pain.
The efficacy of tramadol for the management of moderate to severe postoperative pain has been demonstrated in both inpatients and day surgery patients and, unlike other opioids, tramdol has no clinically relevant effects on respiratory or cardiovascular parameters.
Tacrolimus: a further update of its use in the management of organ transplantation.
The reduced incidence of rejection episodes in renal transplant recipients receiving tacrolimus translated into a better cost effectiveness relative to cyclosporin microemulsion treatment, which was reflected in improved cost effectiveness.
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer.
Overall, cetuximab treatment had an acceptable tolerability profile, with the majority of adverse events being mild or moderate in severity and clinically manageable, and cetUXimab therapy did not exacerbate toxicities commonly associated with chemo- or radiotherapeutic regimens.
Voriconazole : a review of its use in the management of invasive fungal infections.
In large randomised trials, voriconazole was an effective and generally well tolerated primary treatment for candidiasis and invasive aspergillosis in adults and adolescents and provides an alternative option for the treatment of candidiasis, particularly where the causative organism is inherently resistant to other licensed antifungal agents.
Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapy.
The cardioprotective efficacy of dexrazoxane in patients with childhood malignancies is supported by limited data, and the drug is generally well tolerated and has a tolerability profile similar to that of placebo in cancer patients undergoing anthracycline-based chemotherapy.
Tocilizumab: A Review in Rheumatoid Arthritis
- L. Scott
- Medicine, BiologyDrugs
- 1 November 2017
Given its low risk of immunogenicity, the flexibility of IV and SC administration and the convenience of the once-weekly, self-administered, SC regimen, tocilizumab provides an effective treatment for severe, active and progressive RA in adults not previously treated with methotrexate and an effective biologic first- or subsequent-line treatment in adults who have either responded inadequately to or were intolerant of previous therapy with ≥ 1 csDMARD or TNF inhibitor.
Empagliflozin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus
- L. Scott
- 2 October 2014
With its insulin-independent mechanism of action, empagliflozin monotherapy or combination therapy with other antidiabetic drugs, including insulin, provides a useful addition to the therapeutic options for the management of type 2 diabetes.
Baricitinib: A Review in Rheumatoid Arthritis
Once-daily baricitinib, as monotherapy or in combination with methotrexate, is an effective and generally well tolerated emerging treatment for patients with moderate to severe active RA who have responded inadequately to or are intolerant of ≥ 1 DMARD, and extends the options available for this population.
Cefuroxime axetil: an updated review of its use in the management of bacterial infections.
Cefuroxime axetil is an effective and well tolerated treatment in patients with various infections, including otitis media, pharyngitis, sinusitis, CAP and acute exacerbations of chronic bronchitis and may be considered as an empirical therapy for a range of community-acquired infections.
Olmesartan medoxomil: a review of its use in the management of hypertension.
The consistent antihypertensive efficacy during the entire 24-hour dosage interval and good tolerability profile of olmesartan medoxomil, with or without HCTZ, make it a valuable option for the treatment of adult patients with hypertension, including the elderly.