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Tramadol: a review of its use in perioperative pain.
TLDR
The efficacy of tramadol for the management of moderate to severe postoperative pain has been demonstrated in both inpatients and day surgery patients and, unlike other opioids, tramdol has no clinically relevant effects on respiratory or cardiovascular parameters. Expand
Tacrolimus: a further update of its use in the management of organ transplantation.
TLDR
The reduced incidence of rejection episodes in renal transplant recipients receiving tacrolimus translated into a better cost effectiveness relative to cyclosporin microemulsion treatment, which was reflected in improved cost effectiveness. Expand
Cetuximab: a review of its use in squamous cell carcinoma of the head and neck and metastatic colorectal cancer.
TLDR
Overall, cetuximab treatment had an acceptable tolerability profile, with the majority of adverse events being mild or moderate in severity and clinically manageable, and cetUXimab therapy did not exacerbate toxicities commonly associated with chemo- or radiotherapeutic regimens. Expand
Voriconazole : a review of its use in the management of invasive fungal infections.
TLDR
In large randomised trials, voriconazole was an effective and generally well tolerated primary treatment for candidiasis and invasive aspergillosis in adults and adolescents and provides an alternative option for the treatment of candidiasis, particularly where the causative organism is inherently resistant to other licensed antifungal agents. Expand
Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapy.
TLDR
The cardioprotective efficacy of dexrazoxane in patients with childhood malignancies is supported by limited data, and the drug is generally well tolerated and has a tolerability profile similar to that of placebo in cancer patients undergoing anthracycline-based chemotherapy. Expand
Olmesartan medoxomil: a review of its use in the management of hypertension.
TLDR
The consistent antihypertensive efficacy during the entire 24-hour dosage interval and good tolerability profile of olmesartan medoxomil, with or without HCTZ, make it a valuable option for the treatment of adult patients with hypertension, including the elderly. Expand
Telmisartan: a review of its use in the management of hypertension.
TLDR
The consistent antihypertensive efficacy during the entire 24-hour dosage interval and sustained BP-lowering effect in the long term, combined with its favourable tolerability profile, mean that telmisartan is a valuable first-line treatment option for the management of essential hypertension. Expand
Saquinavir: a review of its use in boosted regimens for treating HIV infection.
UNLABELLED Protease inhibitor boosting involves concurrent administration of a protease inhibitor, such as saquinavir, plus a potent inhibitor of cytochrome P450 (CYP) 3A4, usually ritonavir inExpand
Empagliflozin: A Review of Its Use in Patients with Type 2 Diabetes Mellitus
TLDR
With its insulin-independent mechanism of action, empagliflozin monotherapy or combination therapy with other antidiabetic drugs, including insulin, provides a useful addition to the therapeutic options for the management of type 2 diabetes. Expand
Valaciclovir: a review of its long term utility in the management of genital herpes simplex virus and cytomegalovirus infections.
TLDR
Valaciclovir is well tolerated at dosages used to suppress recurrent episodes of genital herpes in immunocompetent and HIV seropositive individuals, with headache being reported most often. Expand
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