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Aurora Kinase A

Known as: Aurora A, AuroraA Kinase, Serine/Threonine-Protein Kinase 15 
An aurora kinase that localizes to the CENTROSOME during MITOSIS and is involved in centrosome regulation and formation of the MITOTIC SPINDLE… 
National Institutes of Health

Related topics

Related topics

39 relations
AURKA geneAURKA wt AlleleAurora A Kinase Inhibitor TAS-119Aurora Kinase Inhibitor

Narrower (3)

Aurka protein, mouseAurka protein, rataur protein, Drosophila

Papers overview

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Review
2009
Review
2009
Discovery and development of aurora kinase inhibitors as anticancer agents.
The process of cell division or mitosis is highly complex and tightly regulated. During this phase of the cell cycle two… 
Highly Cited
2008
Highly Cited
2008
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection.
BACKGROUND Chromosome missegregation and the resulting aneuploidy is a common change in neoplasia. The Aurora kinase A (AURKA… 
Review
2006
Review
2006
Genetic alterations in urothelial bladder carcinoma
New oncogenes and tumor suppressor genes that play an important role in the pathogenesis of urothelial bladder carcinoma have… 
Highly Cited
2006
Highly Cited
2006
Overexpression of Aurora-A kinase promotes tumor cell proliferation and inhibits apoptosis in esophageal squamous cell carcinoma cell line
Aurora-A kinase, a serine/threonine protein kinase, is a potential oncogene. Amplification and overexpression of Aurora-A have… 
Highly Cited
2004
Highly Cited
2004
STK15/Aurora‐A expression in primary breast tumors is correlated with nuclear grade but not with prognosis
DNA amplification on chromosome 20q13 is commonly detected in breast carcinoma and is correlated with poor prognosis. STK15 maps… 
Highly Cited
2004
Highly Cited
2004
High Expression of Aurora-B/Aurora and Ipl1-Like Midbody-Associated Protein (AIM-1) in Astrocytomas
AbstractObjective: Impaired regulation of Aurora-B/AIM-1 expression in human cells causes chromosomal abnormality and instability… 
Highly Cited
2004
Highly Cited
2004
Aberrant quantity and localization of Aurora-B/AIM-1 and survivin during megakaryocyte polyploidization and the consequences of Aurora-B/AIM-1-deregulated expression.
Megakaryocytes skip late anaphase and cytokinesis during endomitosis. We found normal expression and localization of a… 
Highly Cited
2004
Highly Cited
2004
Megakaryocytes express functional Aurora-B kinase in endomitosis.
Endomitosis (EnM) in megakaryocytes (MKs) is characterized by abortion of mitosis in late anaphase and failure of cytokinesis… 
Highly Cited
2003
Highly Cited
2003
Aurora2/BTAK/STK15 is involved in cell cycle checkpoint and cell survival of aggressive non‐Hodgkin's lymphoma
Summary. Non‐Hodgkin's lymphoma (NHL) has a wide biological heterogeneity and shows extremely variable responses to therapeutic… 
2002
2002
Aurora-A Kinase Interacting Protein (AIP), a Novel Negative Regulator of Human Aurora-A Kinase*
Aurora kinases have evolved as a new family of mitotic centrosome- and microtubule-associated kinases that regulate the structure… 
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