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Aurora Kinase Inhibitor

Any substance that inhibits Aurora kinase, a serine/threonine kinase that is involved in mitotic spindle morphology, centrosome function, chromatid… 
National Institutes of Health

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Aurora Kinase A

Broader (1)

Enzyme Inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Dual Targeting of Aurora Kinases with AMG 900 Exhibits Potent Preclinical Activity Against Acute Myeloid Leukemia with Distinct Post-Mitotic Outcomes
Aurora kinase A and B have essential and non-overlapping roles in mitosis, with elevated expression in a subset of human cancers… 
2018
2018
Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib
Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor… 
2017
2017
Reactive oxygen species generation and increase in mitochondrial copy number: new insight into the potential mechanism of cytotoxicity induced by aurora kinase inhibitor, AZD1152-HQPA
Aurora-B kinase overexpression plays important roles in the malignant progression of prostate cancer (PCa). AZD1152-HQPA, as an… 
2016
2016
The radiosensitizing effect of the aurora kinase inhibitors, ENMD-2076, on canine mast cell tumours in vitro.
ENMD-2076 is an aurora kinase inhibitor that also has multi-target tyrosine kinase inhibitor properties. In this study, the mRNA… 
2016
2016
Functional Effects of AKT3 on Aurora Kinase Inhibitor-induced Aneuploidy*
The suppression of mitotic Aurora kinases (AURKs) by AURK inhibitors frequently causes cytokinetic failure, leading to polyploidy… 
2014
2014
Combining the pan-aurora kinase inhibitor AMG 900 with histone deacetylase inhibitors enhances antitumor activity in prostate cancer
Histone deacetylase inhibitors (HDACIs) are being tested in clinical trials for the treatment of solid tumors. While most studies… 
2013
2013
Evaluation of the Aurora Kinase Inhibitor, ZM447439, in Canine Malignant Lymphoid Cells in Vitro
Aurora kinases play an important role in the cell cycle. These enzymes help establish mitotic spindles by directing centrosome… 
2010
2010
Targets and effectors of the cellular response to aurora kinase inhibitor MK-0457 (VX-680) in imatinib sensitive and resistant chronic myelogenous leukemia.
2009
2009
Pha-739358: a pan-aurora kinase inhibitor
PHA-739358 is a small molecule 3-aminopyrazole derivative with low nanomolar activity against all aurora kinases (AKs). It also… 
2007
2007
Cellular and molecular mechanisms of action of AS703569, a novel aurora kinase inhibitor, in human cancer cell lines
C197 Background Inhibition of aurora kinases in tumor cells results in endoreduplication and cell death. AS703569 (formerly known… 
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