Discovery and development of aurora kinase inhibitors as anticancer agents.

@article{Pollard2009DiscoveryAD,
  title={Discovery and development of aurora kinase inhibitors as anticancer agents.},
  author={John Robert Pollard and Michael Mortimore},
  journal={Journal of medicinal chemistry},
  year={2009},
  volume={52 9},
  pages={2629-51}
}
The process of cell division or mitosis is highly complex and tightly regulated. During this phase of the cell cycle two identical copies of DNA are completely separated by the microtubule spindle apparatus and packaged into two daughter cells (see Figure 1 for a description of mitosis). Inappropriate completion of mitosis leads to genetic instability and, frequently, cells that contain nondiploid DNA content (less than or greater than 2 copies of DNA). These phenotypes are hallmarks of nearly… CONTINUE READING
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