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Aurora A Kinase Inhibitor TAS-119

Known as: TAS-119, TAS-2104 
An orally bioavailable inhibitor of the serine/threonine protein kinase aurora A, with potential antimitotic and antineoplastic activities. Upon… Expand
National Institutes of Health

Papers overview

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2020
2020
TAS-119 is a novel orally active, selective inhibitor of Aurora kinase A identified as a clinical candidate for efficacy testing… Expand
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2019
2019
3063Background: AurA is a serine threonine kinase regulating cell division and cell cycle progression and has a role in… Expand
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2019
2019
3031Background: AurA is a key regulator of cell division, including mitotic spindle assembly. However, elevated levels of AurA… Expand
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2014
2014
Material and Methods: For in vitro experiments, cells were exposed to paclitaxel and/or TAS-119. Cell viability was determined by… Expand
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2014
2014
Material and Methods: Cell proliferation of a panel of 240 human tumorderived cell lines was measured by the signal intensity of… Expand
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2014
2014
Material and Methods: For in vitro experiments, cells were exposed to paclitaxel and/or TAS-119. Cell viability was determined by… Expand
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2013
2013
  • T. Utsugi
  • Japanese journal of clinical oncology
  • 2013
  • Corpus ID: 16915823
Many pharmaceutical companies worldwide specialize in oncology drug development and marketing. Among them, we have continued to… Expand
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