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Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelial–mesenchymal transition
TLDR
It is shown that GSK-3β binds to and phosphorylates Snail at two consensus motifs to dually regulate the function of this protein and together function as a molecular switch for many signalling pathways that lead to EMT. Expand
Nuclear localization of EGF receptor and its potential new role as a transcription factor
TLDR
It is demonstrated that nuclear EGFR is strongly correlated with highly proliferating activities of tissues and associated with promoter region of cyclin D1 in vivo, suggesting that EGFR might function as a transcription factor to activate genes required for highly proliferationating activities. Expand
HER-2/neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation
TLDR
This study indicates that blocking the Akt pathway mediated by HER-2/neu would increase the cytotoxic effect of DNA-damaging drugs in tumour cells with wild-type p53. Expand
Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene
TLDR
It is shown that EGF induces EGFR-expressing cancer cells to undergo a transition from the epithelial to the spindle-like mesenchymal morphology and induce cancer cell EMT via STAT3-mediated TWIST gene expression. Expand
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
TLDR
Evidence is provided for the negative regulation of FOXO factors by IKK as a key mechanism for promoting cell growth and tumorigenesis by showing that IkappaB kinase physically interacts with, phosphorylates, and inhibits FOXO3a independent of Akt and causes proteolysis of FOXo3a via the Ub-dependent proteasome pathway. Expand
Cytoplasmic localization of p21Cip1/WAF1 by Akt-induced phosphorylation in HER-2/neu-overexpressing cells
TLDR
It is shown that HER-2/neu-mediated cell growth requires the activation of Akt, which associates with p 21Cip1/WAF1 and phosphorylates it at threonine 145, resulting in cytoplasmic localization of p21Cip 1/Waf1. Expand
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
TLDR
This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425. Expand
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin.
TLDR
A mechanism by which HBV-X protein (HBX) upregulates beta-catenin through a docking motif of GSK-3beta is reported, which is supported by immunohistochemical staining in different human tumors, including cancers of the liver, breast, kidney, and stomach. Expand
Akt-Mediated Phosphorylation of EZH2 Suppresses Methylation of Lysine 27 in Histone H3
TLDR
It is shown that Akt phosphorylates EZH2 at serine 21 and suppresses its methyltransferase activity by impeding EZh2 binding to histone H3, which results in a decrease of lysine 27 trimethylation and derepression of silenced genes. Expand
IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a
TLDR
Evidence is provided for the negative regulation of FOXO factors by IKK as a key mechanism for promoting cell growth and tumorigenesis by showing that IkappaB kinase physically interacts with, phosphorylates, and inhibits FOXO3a independent of Akt and causes proteolysis of FOXo3a via the Ub-dependent proteasome pathway. Expand
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