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Antigen Targeting

Antigen Targeting involves specific and high affinity non-covalent interaction (binding) of an antibody reagent through intermolecular physical… Expand
National Institutes of Health

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Related topics

3 relations
AntigensImmunityMoAb Bombesin (ITC-D)

Papers overview

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Highly Cited
2011
Highly Cited
2011
Increasing vaccine potency through exosome antigen targeting.
While many tumor associated antigens (TAAs) have been identified in human cancers, efforts to develop efficient TAA "cancer… Expand
Highly Cited
2010
Highly Cited
2010
Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR.
We evaluated human CD8(+) T-cell responses generated by targeting antigens to dendritic cells (DCs) through various lectin… Expand
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Highly Cited
2010
Highly Cited
2010
Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A
DC NK lectin group receptor‐1 (DNGR‐1, also known as CLEC9A) is a C‐type lectin receptor expressed by mouse CD8α+ DC and by their… Expand
Highly Cited
2008
Highly Cited
2008
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
The mouse CD8alpha+ DC subset excels at cross-presentation of antigen, which can elicit robust CTL responses. A receptor allowing… Expand
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Highly Cited
2007
Highly Cited
2007
Exploiting lymphatic transport and complement activation in nanoparticle vaccines
Antigen targeting and adjuvancy schemes that respectively facilitate delivery of antigen to dendritic cells and elicit their… Expand
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Highly Cited
2006
Highly Cited
2006
The dominant role of CD8+ dendritic cells in cross-presentation is not dictated by antigen capture.
Mouse spleens contain three populations of conventional (CD11c(high)) dendritic cells (DCs) that play distinct functions. The CD8… Expand
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Highly Cited
2006
Highly Cited
2006
Antigen targeting to dendritic cells elicits long-lived T cell help for antibody responses
Resistance to several prevalent infectious diseases requires both cellular and humoral immune responses. T cell immunity is… Expand
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Highly Cited
2005
Highly Cited
2005
Design of Soluble Recombinant T Cell Receptors for Antigen Targeting and T Cell Inhibition*
The use of recombinant T cell receptors (TCRs) to target therapeutic interventions has been hindered by the naturally low… Expand
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Highly Cited
2004
Highly Cited
2004
In Vivo Targeting of Antigens to Maturing Dendritic Cells via the DEC-205 Receptor Improves T Cell Vaccination
The prevention and treatment of prevalent infectious diseases and tumors should benefit from improvements in the induction of… Expand
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Highly Cited
1999
Highly Cited
1999
Modulation of the humoral immune response by antibody-mediated antigen targeting to complement receptors and Fc receptors.
During an ongoing immune response, immune complexes, composed of Ag, complement factors, and Igs, are formed that can interact… Expand
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