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Resident and pro-inflammatory macrophages in the colon represent alternative context-dependent fates of the same Ly6Chi monocyte precursors
TLDR
Phenotypic analysis of human intestinal mφ indicates that analogous processes occur in the normal and Crohn's disease ileum, and shows for the first time that resident and inflammatory m φ in the intestine represent alternative differentiation outcomes of the same precursor. Expand
Intestinal CD103+, but not CX3CR1+, antigen sampling cells migrate in lymph and serve classical dendritic cell functions
TLDR
Findings indicate that selectively CD103+ DCs serve classical DC functions and initiate adaptive immune responses in local LNs, whereas CX3CR1+ populations might modulate immune responses directly in the mucosa and serve as first line barrier against invading enteropathogens. Expand
Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans
TLDR
Small intestinal CD103+ DCs represent a potential novel target for regulating human intestinal inflammatory responses and are shown to represent a tissue-derived migratory population that plays a central role in presenting orally derived soluble antigen to CD8+ and CD4+ T cells. Expand
Regional specialization within the intestinal immune system
TLDR
The anatomical and physiological distinctions that are observed in the small and large intestines are detailed, and it is suggested how these may account for the diversity in the immune apparatus that is seen throughout the intestine. Expand
IRF4 transcription-factor-dependent CD103(+)CD11b(+) dendritic cells drive mucosal T helper 17 cell differentiation.
TLDR
It is demonstrated that intestinal CD103(+)CD11b(+) DC survival was dependent on interferon regulatory factor 4 (IRF4), and results suggest a central role for IRF4-dependent, IL-6 producing CD103 (+) CD11b (+) DCs in intestinal Th17 cell differentiation. Expand
Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract.
TLDR
Results show that type 1 fimbriae in the genetic background of a uropathogenic strain contribute to the pathogenesis of E. coli in the urinary tract. Expand
Functional specialization of gut CD103+ dendritic cells in the regulation of tissue-selective T cell homing
TLDR
Results demonstrate a unique function for LP-derived CD103+ MLN DCs in the generation of gut-tropic effector T cells in vitro. Expand
Essential role for CD103 in the T cell–mediated regulation of experimental colitis
TLDR
Analysis of the functional role of CD103 in intestinal immune regulation using the T cell transfer model of colitis suggests that CD103+ and CD103− DCs represent functionally distinct subsets and thatCD103 expression on DCs influences the balance between effector and regulatory T cell activity in the intestine. Expand
The sensing of environmental stimuli by follicular dendritic cells promotes immunoglobulin A generation in the gut.
TLDR
It is shown here that direct stimulation of FDCs by bacterial products and retinoic acid synergistically enhanced the expression of the chemokine CXCL13, the survival factor BAFF, and molecules that facilitate the secretion and activation of the cytokine TGF-beta1. Expand
Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed
TLDR
The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR/CCR-9, both in T cell development and the mucosal immune response, and proposes the designation CCR-9 for this chemokine receptor. Expand
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