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Innate Antiviral Responses by Means of TLR7-Mediated Recognition of Single-Stranded RNA
TLDR
These results identify ssRNA as a ligand for TLR7 and suggest that cells of the innate immune system sense endosomal ssRNA to detect infection by RNA viruses.
RIG-I-Mediated Antiviral Responses to Single-Stranded RNA Bearing 5'-Phosphates
TLDR
It is shown that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5′-phosphates, and suggested that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.
Syk-dependent cytokine induction by Dectin-1 reveals a novel pattern recognition pathway for C type lectins.
TLDR
It is demonstrated that the beta-glucan receptor Dectin-1, a yeast binding C type lectin known to synergize with TLR2 to induce TNF alpha and IL-12, can also promote synthesis of IL-2 andIL-10 through phosphorylation of the membrane proximal tyrosine in the cytoplasmic domain and recruitment of Syk kinase.
Characterization of human DNGR-1+ BDCA3+ leukocytes as putative equivalents of mouse CD8α+ dendritic cells
TLDR
The characterization of human DNGR-1+ BDCA3hi DCs and the ability to grow them in vitro opens the door for exploiting this subset in immunotherapy.
Cytosolic Sensing of Viruses
TLDR
Recent advances in the molecular understanding of cytosolic nucleic acid detection and its evasion by viruses are detailed.
Identification of a dendritic cell receptor that couples sensing of necrosis to immunity
TLDR
It is shown that CD8α+ dendritic cells use CLEC9A (also known as DNGR-1), a recently-characterized C-type lectin, to recognize a preformed signal that is exposed on necrotic cells and functions as a SYK-coupled C- type lectin receptor to mediate sensing of necrosis by the principal d endritic-cell subset involved in regulating cross-priming to cell-associated antigens.
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
TLDR
It is concluded that DNGR-1 is a novel, highly specific marker of mouse and human DC subsets that can be exploited for CTL cross-priming and tumor therapy.
CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1‐inducing role of mesenteric lymph node macrophages during colitis
TLDR
It is demonstrated that, using CD64 expression, MΦs can be distinguished from DCs in the intestine of both mice and humans and how inflammation impacts this pathway is determined, and it is shown that T cell‐mediated colitis is associated with massive recruitment of monocytes to the intestine and the mesenteric lymph node (MLN).
GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c(+)MHCII(+) Macrophages and Dendritic Cells.
TLDR
It is demonstrated that CD11c(+)MHCII(+) BMDCs are in fact a heterogeneous group of cells that comprises conventional DCs and monocyte-derived macrophages, and have important implications for the interpretation of a vast array of data obtained with DC culture systems.
Signaling by myeloid C-type lectin receptors in immunity and homeostasis.
TLDR
The signaling properties of myeloid CLRs are reviewed and how they impact the role of myELoid cells in innate and adaptive immunity is reviewed.
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