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Androstanes

Known as: Androstanes [Chemical/Ingredient], androstane, androstane compound 
The family of steroids from which the androgens are derived.
National Institutes of Health

Related topics

Related topics

48 relations
1250 MG Testosterone 0.0162 MG/MG Topical Gel [Androgel]3 ML testosterone undecanoate 250 MG/ML Injection5000 MG Testosterone 0.01 MG/MG Topical Gel [Testim]C19 steroid

Narrower (23)

17-acetamidoandrostane17-isopentyloxy-4-azaandrostane3-acetoxy-17-prolylaminoandrostane6-oxonimonol

Broader (1)

Steroids

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
Highly Cited
2007
Highly Cited
2007
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.
Review
2005
Review
2005
Induction of phase I, II and III drug metabolism/transport by xenobiotics
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs… 
Highly Cited
2003
Highly Cited
2003
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is… 
Highly Cited
2003
Highly Cited
2003
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight… 
Highly Cited
2003
Highly Cited
2003
Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes*
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical… 
Highly Cited
2002
Highly Cited
2002
Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… 
Highly Cited
2002
Highly Cited
2002
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… 
Highly Cited
2000
Highly Cited
2000
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR… 
Highly Cited
1998
Highly Cited
1998
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
The orphan receptor CAR-β (ref. 1) binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a… 
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