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Androstanes
Known as:
Androstanes [Chemical/Ingredient]
, androstane
, androstane compound
The family of steroids from which the androgens are derived.
National Institutes of Health
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Related topics
Related topics
48 relations
1250 MG Testosterone 0.0162 MG/MG Topical Gel [Androgel]
3 ML testosterone undecanoate 250 MG/ML Injection
5000 MG Testosterone 0.01 MG/MG Topical Gel [Testim]
C19 steroid
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Narrower (23)
17-acetamidoandrostane
17-isopentyloxy-4-azaandrostane
3-acetoxy-17-prolylaminoandrostane
6-oxonimonol
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Broader (1)
Steroids
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
The human hepatoma HepaRG cells: a highly differentiated model for studies of liver metabolism and toxicity of xenobiotics.
A. Guillouzo
,
A. Corlu
,
C. Aninat
,
D. Glaise
,
F. Morel
,
C. Guguen-Guillouzo
Chemico-biological interactions
2007
Corpus ID: 43907700
Highly Cited
2007
Highly Cited
2007
Cytochrome P450 enzyme levels in HepG2 cells and cryopreserved primary human hepatocytes and their induction in HepG2 cells.
W. Westerink
,
W. Schoonen
Toxicology in vitro : an international journal…
2007
Corpus ID: 21396586
Review
2005
Review
2005
Induction of phase I, II and III drug metabolism/transport by xenobiotics
Changjiang Xu
,
C. Li
,
A. Kong
Archives of pharmacal research
2005
Corpus ID: 14402974
Drug metabolizing enzymes (DMEs) play central roles in the metabolism, elimination and detoxification of xenobiotics and drugs…
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Highly Cited
2003
Highly Cited
2003
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
Wendong Huang
,
Jun Zhang
,
+4 authors
D. Moore
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 25714560
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is…
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Highly Cited
2003
Highly Cited
2003
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor
W. Xie
,
Mei-Fei Yeuh
,
+6 authors
R. Evans
Proceedings of the National Academy of Sciences…
2003
Corpus ID: 30050943
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight…
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Highly Cited
2003
Highly Cited
2003
Identification of a Novel Human Constitutive Androstane Receptor (CAR) Agonist and Its Use in the Identification of CAR Target Genes*
J. M. Maglich
,
D. Parks
,
+8 authors
John T. Moore
The Journal of Biological Chemistry
2003
Corpus ID: 44950612
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical…
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Highly Cited
2002
Highly Cited
2002
Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*
H. R. Kast
,
B. Goodwin
,
+7 authors
P. Edwards
The Journal of Biological Chemistry
2002
Corpus ID: 36917131
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the…
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Highly Cited
2002
Highly Cited
2002
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
J. M. Maglich
,
C. Stoltz
,
B. Goodwin
,
D. Hawkins-Brown
,
John T. Moore
,
S. Kliewer
Molecular pharmacology
2002
Corpus ID: 13374225
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body…
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Highly Cited
2000
Highly Cited
2000
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands*
L. Moore
,
D. Parks
,
+9 authors
S. Kliewer
The Journal of Biological Chemistry
2000
Corpus ID: 33055587
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR…
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Highly Cited
1998
Highly Cited
1998
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
B. M. Forman
,
Iphigenia Tzameli
,
+5 authors
D. Moore
Nature
1998
Corpus ID: 4387623
The orphan receptor CAR-β (ref. 1) binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a…
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