Androstanes

Known as: Androstanes [Chemical/Ingredient], androstane, androstane compound 
The family of steroids from which the androgens are derived.
National Institutes of Health

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17-acetamidoandrostane3-acetoxy-17-prolylaminoandrostane6-oxonimonolANQ 9040
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5000 MG Testosterone 0.01 MG/MG Topical Gel [Testim]C19 steroidDanazolFluoxymesterone
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Broader (1)

Steroids

Papers overview

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Highly Cited
2004
Highly Cited
2004
The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice.
Hepatocellular carcinoma (HCC) is known to progress through a step often called tumor promotion. Phenobarbital (PB) is the… (More)
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Highly Cited
2003
Highly Cited
2003
Control of steroid, heme, and carcinogen metabolism by nuclear pregnane X receptor and constitutive androstane receptor.
Through a multiplex promoter spanning 218 kb, the phase II UDP-glucuronosyltransferase 1A (UGT1) gene encodes at least eight… (More)
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Highly Cited
2003
Highly Cited
2003
Induction of bilirubin clearance by the constitutive androstane receptor (CAR).
Bilirubin clearance is one of the numerous important functions of the liver. Defects in this process result in jaundice, which is… (More)
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Highly Cited
2003
Highly Cited
2003
Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.
The orphan nuclear constitutive androstane receptor (CAR) is proposed to play a central role in the response to xenochemical… (More)
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Highly Cited
2002
Highly Cited
2002
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor.
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the… (More)
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Highly Cited
2002
Highly Cited
2002
Nuclear pregnane x receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification.
The nuclear pregnane X receptor (PXR) and constitutive androstane receptor (CAR) play central roles in protecting the body… (More)
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Highly Cited
2002
Highly Cited
2002
Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.
The NR1I subfamily of nuclear receptors contains a phylogenetically diverse array of receptors related to the mammalian pregnane… (More)
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Highly Cited
2000
Highly Cited
2000
Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.
Xenobiotics induce the transcription of cytochromes P450 (CYPs) 2B and 3A through the constitutive androstane receptor (CAR… (More)
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Highly Cited
2000
Highly Cited
2000
Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation.
The barbiturate phenobarbital induces the transcription of cytochromes P450 (CYPs) 2B through the constitutive androstane… (More)
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Highly Cited
1998
Highly Cited
1998
Androstane metabolites bind to and deactivate the nuclear receptor CAR-β
The orphan receptor CAR-β (ref. 1) binds DNA as a heterodimer with the retinoid-X receptor and activates gene transcription in a… (More)
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