The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference

@article{Rosellini2001TheTM,
  title={The testosterone metabolite and neurosteroid 3$\alpha$-androstanediol may mediate the effects of testosterone on conditioned place preference},
  author={Robert A. Rosellini and Bruce B. Svare and Madeline E. Rhodes and Cheryl Anne Frye},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={162-171}
}
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72 Citations
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72 Citations

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Self-administration of 3α-androstanediol increases locomotion and analgesia and decreases aggressive behavior of male hamsters
The anabolic steroids testosterone propionate and nandrolone, but not 17alpha-methyltestosterone, induce conditioned place preference in adult mice.
The nucleus accumbens as a site of action for rewarding properties of testosterone and its 5α-reduced metabolites
Mnemonic effects of testosterone and its 5α-reduced metabolites in the conditioned fear and inhibitory avoidance tasks
CYP7B1 Enzyme Deletion Impairs Reproductive Behaviors in Male Mice.
TLDR
A novel role for the CYP7B1 enzyme in the regulation of male reproductive behaviors is suggested and seems to be due to their inability to distinguish olfactory cues from a behavioral estrus female.
Some rewarding effects of androgens may be mediated by actions of its 5α-reduced metabolite 3α-androstanediol
  • C. Frye
  • Biology, Psychology
    Pharmacology Biochemistry and Behavior
  • 2007
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Androgen dependence in hamsters: Overdose, tolerance, and potential opioidergic mechanisms
Androgens with activity at estrogen receptor beta have anxiolytic and cognitive-enhancing effects in male rats and mice
Psychomotor and rewarding properties of the neurosteroids dehydroepiandrosterone sulphate and androsterone: effects on monoamine and steroid metabolism.
TLDR
Although psychobehavioral and neurochemical effects of DHEAS and androsterone differ in several aspects; both neurosteroids have rewarding properties at certain dose ranges, suggesting their likely involvement in addictions, which entail different mechanisms.
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References

SHOWING 1-10 OF 51 REFERENCES
The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference
Analgesic effects of the neurosteroid 3α-androstanediol
Rewarding Effect of the Neuroactive Steroid 3α-hydroxy-5α-pregnan-20-one in Mice
Behavioral effects of 3α-androstanediol I: modulation of sexual receptivity and promotion of GABA-stimulated chloride flux
Direct effects of the anabolic/androgenic steroids, stanozolol and 17α-methyltestosterone, on benzodiazepine binding to the γ-aminobutyric acidA receptor
Chronic anabolic-androgenic steroid treatment affects brain GABA(A) receptor-gated chloride ion transport.
ANDROGENIC NEUROSTEROIDS: ANTI-SEIZURE EFFECTS IN AN ANIMAL MODEL OF EPILEPSY
Behavioral effects of 3a-androstanediol II: Hypothalamic and preoptic area actions via a GABAergic mechanism
Treatment with an Anabolic-Androgenic Steroid Affects Anxiety-Related Behavior and Alters the Sensitivity of Cortical GABAA Receptors in the Rat
TLDR
The putative psychotropic effect of the anabolic-androgenic steroid, testosterone propionate (TP), was determined in intact adult male rats after 1 or 2 weeks of continued exposure via subcutaneously implanted capsules and the agonist effects of reduced androgen metabolites at the GABAA receptor and the possible development of tolerance to these effects are discussed.
Rewarding Properties of Testosterone in Intact Male Mice A Pilot Study
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