The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference

@article{Rosellini2001TheTM,
  title={The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference},
  author={R. Rosellini and B. Svare and M. Rhodes and C. Frye},
  journal={Brain Research Reviews},
  year={2001},
  volume={37},
  pages={162-171}
}
  • R. Rosellini, B. Svare, +1 author C. Frye
  • Published 2001
  • Medicine, Biology
  • Brain Research Reviews
  • Testosterone (T) and pregnane neurosteroids can enhance conditioned place preference (CPP). The present experiment examined CPP produced by T and its androgenic metabolite dihydrotestosterone (DHT) and 3alpha-Androstanediol (3alpha-diol; an androstane neurosteroid). Administration of 3alpha-diol (>DHT>T) to intact male Long-Evans rats, 1.0 mg daily for six days, 30 min prior to exposure to the non-preferred side of the CPP chamber significantly increased preference for the non-preferred side of… CONTINUE READING
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