Activation of the Cooh-Terminal Src Kinase (Csk) by Camp-Dependent Protein Kinase Inhibits Signaling through the T Cell Receptor
- T. Vang, K. Torgersen, K. Taskén
- BiologyJournal of Experimental Medicine
- 19 February 2001
A mechanism whereby PKA through activation of Csk intersects signaling by Src kinases and inhibits T cell activation is proposed, which leads to a two- to fourfold increase in Csk activity that is necessary for cAMP-mediated inhibition of TCR-induced interleukin 2 secretion.
Steroid binding in polyacrylamide gels. Quantitation at steady state conditions.
- E. Ritzén, F. S. French, S. Weddington, S. Nayfeh, V. Hansson
- Biology, ChemistryJournal of Biological Chemistry
- 25 October 1974
Using steady state gel electrophoresis of nonlabeled samples and samples saturated with labeled steroid, concentrations of testicular androgen-binding protein in rat and rabbit, as well as concentration of rabbit, monkey, and human serum testosterone-binding globulin have been measured.
Structure, function, and regulation of human cAMP-dependent protein kinases.
- K. Tasken, B. Skålhegg, T. Jahnsen
- BiologyAdvances in second messenger and phosphoprotein…
- 1997
Localization of a novel human A-kinase-anchoring protein, hAKAP220, during spermatogenesis.
- N. Reinton, P. Collas, K. Tasken
- BiologyDevelopmental Biology
- 1 July 2000
Using a combination of protein kinase A type II overlay screening, rapid amplification of cDNA ends, and database searches, a contig of 9923 bp was assembled and characterized in which the open…
Location of cAMP-dependent protein kinase type I with the TCR-CD3 complex.
- B. Skålhegg, K. Tasken, V. Hansson, H. Huitfeldt, T. Jahnsen, T. Lea
- BiologyScience
- 7 January 1994
Immunocytochemistry and immunoprecipitation studies of the molecular mechanism by which cAKI inhibits T CR-CD3-dependent T cell replication demonstrated that regulatory subunit I alpha, along with its associated kinase activity, translocated to and interacted with the TCR- CD3 complex during T cell activation and capping.
Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase.
- S. Beebe, O. Oyen, M. Sandberg, A. Frøysa, V. Hansson, T. Jahnsen
- BiologyMolecular Endocrinology
- 1 March 1990
The molecular cloning of a third isoform of C, from a human testis cDNA library, as well as the isolation of human cDNAs for C alpha and C beta are reported, suggesting that C gamma may be distinct in its protein substrate specificity or its interaction with the different regulatory subunits.
Cyclic AMP-dependent protein kinase type I mediates the inhibitory effects of 3',5'-cyclic adenosine monophosphate on cell replication in human T lymphocytes.
- B. Skålhegg, B. Landmark, S. Døskeland, V. Hansson, T. Lea, T. Jahnsen
- Biology, ChemistryJournal of Biological Chemistry
- 5 August 1992
Novel isozymes of cAMP-dependent protein kinase exist in human cells due to formation of RI alpha-RI beta heterodimeric complexes.
- K. Tasken, B. Skålhegg, V. Hansson
- BiologyJournal of Biological Chemistry
- 5 October 1993
Molecular cloning, cDNA structure and deduced amino acid sequence for a type I regulatory subunit of cAMP-dependent protein kinase from human testis.
- M. Sandberg, K. Tasken, O. Oyen, V. Hansson, T. Jahnsen
- Biology, ChemistryBiochemical and Biophysical Research…
- 31 December 1987
Protein kinase A type I antagonist restores immune responses of T cells from HIV‐infected patients
- E. Aandahl, P. Aukrust, K. Taskén
- Biology, MedicineThe FASEB Journal
- 1 July 1998
Follow‐up of patients after initiation of highly active antiretroviral treatment revealed that a majority of patients have a persistent T cell dysfunction that is normalized by incubation of T cells with Rp‐8‐Br‐cAMPS, implying that increased activation of PKA type I may contribute to the progressive Tcell dysfunction in HIV infection.
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