Agomelatine

 
National Institutes of Health

Topic mentions per year

Topic mentions per year

1998-2017
020406019982017

Papers overview

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Highly Cited
2007
Highly Cited
2007
This open study evaluates the effect of agomelatine, a melatonergic receptor agonist and 5-HT2C antagonist antidepressant, on… (More)
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Highly Cited
2007
Highly Cited
2007
Current antidepressants used in major depressive disorder (MDD) are still not efficacious enough for many patients due to high… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE Patients with major depressive disorder (MDD) experience sleep disturbances that may be worsened by some antidepressant… (More)
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2007
2007
OBJECTIVES Agomelatine has been shown to be safe and efficient in the treatment of major depressive disorder at 25 mg daily. The… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Antidepressant treatments increase neural plasticity and adult neurogenesis, especially in the hippocampus. Here, we… (More)
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Highly Cited
2006
Highly Cited
2006
The efficacy and safety of flexible dosing with the antidepressant agomelatine (25-50 mg/day) was evaluated in a 6-week, double… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To study agomelatine (S 20098), a potent agonist at melatonin receptors and antagonist at serotonin-2C (5-HT(2C… (More)
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Highly Cited
2003
Highly Cited
2003
Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C… (More)
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Highly Cited
2003
Highly Cited
2003
Chronic mild stress (CMS), a well-validated model of depression, was used to study the effects of the melatonin agonist and… (More)
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Highly Cited
2002
Highly Cited
2002
Agomelatine (S 20098) has a unique and new pharmacological profile. It is a melatoninergic agonist and selective antagonist of 5… (More)
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