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Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. This response forms the major evidence for theExpand
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Effect of acute antidepressant administration on negative affective bias in depressed patients.
OBJECTIVE Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. TheExpand
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Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
Background The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging. Aims To investigateExpand
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Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.
OBJECTIVE Antidepressants that inhibit the reuptake of serotonin (SSRIs) or norepinephrine (SNRIs) are effective in the treatment of disorders such as depression and anxiety. Cognitive psychologicalExpand
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Tryptophan depletion decreases the recognition of fear in female volunteers
RationaleSerotonergic processes have been implicated in the modulation of fear conditioning in humans, postulated to occur at the level of the amygdala. The processing of other fear-relevant cues,Expand
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Serotonin and emotional processing: Does it help explain antidepressant drug action?
  • C. Harmer
  • Psychology, Medicine
  • Neuropharmacology
  • 1 November 2008
There is growing interest in the effects of antidepressant drug treatment on measures of emotional processing. Such actions may help us understand the role of monoamines in emotional dysfunction inExpand
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Lateral Prefrontal Cortex Mediates the Cognitive Modification of Attentional Bias
Background A tendency to orient attention toward threatening stimuli may be involved in the etiology of anxiety disorders. In keeping with this, both psychological and pharmacological treatments ofExpand
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Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment
Background Selective serotonin reuptake inhibitors (SSRIs) are popular medications for anxiety and depression, but their effectiveness, particularly in patients with prominent symptoms of loss ofExpand
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The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis
The 5-HTTLPR polymorphism has been widely regarded as a potential genetic risk factor for affective disorders. Consistent with this, this polymorphism has been associated with altered amygdalaExpand
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Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
RationaleThere is now compelling evidence for a link between enteric microbiota and brain function. The ingestion of probiotics modulates the processing of information that is strongly linked toExpand
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