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- Publications
- Influence
Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
- C. Harmer, Z. Bhagwagar, D. Perrett, B. Völlm, P. Cowen, G. Goodwin
- Psychology, Medicine
- Neuropsychopharmacology
- 2003
Enhancement of serotonin neurotransmission plays an important role in the antidepressant response to agents presently available to treat depression. This response forms the major evidence for the… Expand
Effect of acute antidepressant administration on negative affective bias in depressed patients.
- C. Harmer, U. O'sullivan, +5 authors P. Cowen
- Psychology, Medicine
- The American journal of psychiatry
- 1 October 2009
OBJECTIVE
Acute administration of an antidepressant increases positive affective processing in healthy volunteers, an effect that may be relevant to the therapeutic actions of these medications. The… Expand
Why do antidepressants take so long to work? A cognitive neuropsychological model of antidepressant drug action
- C. Harmer, G. Goodwin, P. Cowen
- Medicine, Psychology
- British Journal of Psychiatry
- 1 August 2009
Background The neuropharmacological actions of antidepressants are well characterised but our understanding of how these changes translate into improved mood are still emerging. Aims To investigate… Expand
Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition.
- C. Harmer, N. C. Shelley, P. Cowen, G. Goodwin
- Psychology, Medicine
- The American journal of psychiatry
- 1 July 2004
OBJECTIVE
Antidepressants that inhibit the reuptake of serotonin (SSRIs) or norepinephrine (SNRIs) are effective in the treatment of disorders such as depression and anxiety. Cognitive psychological… Expand
Tryptophan depletion decreases the recognition of fear in female volunteers
- C. Harmer, R. Rogers, E. Tunbridge, P. Cowen, G. Goodwin
- Psychology, Medicine
- Psychopharmacology
- 4 April 2003
RationaleSerotonergic processes have been implicated in the modulation of fear conditioning in humans, postulated to occur at the level of the amygdala. The processing of other fear-relevant cues,… Expand
Serotonin and emotional processing: Does it help explain antidepressant drug action?
- C. Harmer
- Psychology, Medicine
- Neuropharmacology
- 1 November 2008
There is growing interest in the effects of antidepressant drug treatment on measures of emotional processing. Such actions may help us understand the role of monoamines in emotional dysfunction in… Expand
Lateral Prefrontal Cortex Mediates the Cognitive Modification of Attentional Bias
- M. Browning, E. Holmes, S. Murphy, G. Goodwin, C. Harmer
- Psychology, Medicine
- Biological Psychiatry
- 15 May 2010
Background A tendency to orient attention toward threatening stimuli may be involved in the etiology of anxiety disorders. In keeping with this, both psychological and pharmacological treatments of… Expand
Diminished Neural Processing of Aversive and Rewarding Stimuli During Selective Serotonin Reuptake Inhibitor Treatment
Background Selective serotonin reuptake inhibitors (SSRIs) are popular medications for anxiety and depression, but their effectiveness, particularly in patients with prominent symptoms of loss of… Expand
The effect of the serotonin transporter polymorphism (5-HTTLPR) on amygdala function: a meta-analysis
- S. Murphy, R. Norbury, +4 authors M. Munafò
- Psychology, Medicine
- Molecular Psychiatry
- 1 April 2013
The 5-HTTLPR polymorphism has been widely regarded as a potential genetic risk factor for affective disorders. Consistent with this, this polymorphism has been associated with altered amygdala… Expand
Prebiotic intake reduces the waking cortisol response and alters emotional bias in healthy volunteers
- K. Schmidt, P. Cowen, C. Harmer, G. Tzortzis, Steven Errington, P. W. Burnet
- Psychology, Medicine
- Psychopharmacology
- 3 December 2014
RationaleThere is now compelling evidence for a link between enteric microbiota and brain function. The ingestion of probiotics modulates the processing of information that is strongly linked to… Expand