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S 20098

Known as: S-20098, S20098 
 
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
Agomelatine (S20098) is a novel antidepressant drug with melatonergic agonist and 5-HT2C receptor antagonist properties… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Antidepressant treatments increase neural plasticity and adult neurogenesis, especially in the hippocampus. Here, we… Expand
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE To study agomelatine (S 20098), a potent agonist at melatonin receptors and antagonist at serotonin-2C (5-HT(2C… Expand
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Highly Cited
2003
Highly Cited
2003
Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C… Expand
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Highly Cited
1997
Highly Cited
1997
The phase-shifting capacity and thermoregulatory effects of a single oral administration at 18 h of melatonin (5 mg) or S-20098… Expand
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Highly Cited
1997
Highly Cited
1997
Abstract We have identified subtype selective agonists, partial agonists and antagonists, which distinguish the human recombinant… Expand
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Highly Cited
1997
Highly Cited
1997
The pineal hormone melatonin has been implicated in the circadian regulation of sleep. In a crossover design, we investigated the… Expand
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Highly Cited
1996
Highly Cited
1996
The present study determined first the dose-response (0.5 to 10 mg.kg-1) to daily oral administration of S-20098, a melatonin… Expand
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Highly Cited
1996
Highly Cited
1996
We studied the effects of drugs related to melatonin on neuronal firing activity in the suprachiasmatic nucleus, intergeniculate… Expand
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Highly Cited
1993
Highly Cited
1993
In human delayed sleep-phase syndrome (DSPS), sleep onset and wake times occur far later than normal. In the population, DSPS may… Expand
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