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S 20098

Known as: S-20098, S20098 
National Institutes of Health

Papers overview

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Review
2010
Review
2010
Objective: To present an updated, comprehensive review on clinical and pre-clinical studies on agomelatine. Method: A MEDLINE… Expand
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Highly Cited
2006
Highly Cited
2006
To confirm the antidepressant-like activity of agomelatine (S 20098), a melatonin agonist and 5-hydroxytryptamine2C antagonist… Expand
Highly Cited
2006
Highly Cited
2006
BACKGROUND Antidepressant treatments increase neural plasticity and adult neurogenesis, especially in the hippocampus. Here, we… Expand
Highly Cited
2004
Highly Cited
2004
OBJECTIVE To study agomelatine (S 20098), a potent agonist at melatonin receptors and antagonist at serotonin-2C (5-HT(2C… Expand
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Highly Cited
2003
Highly Cited
2003
Agomelatine (S20098) displayed pKi values of 6.4 and 6.2 at native (porcine) and cloned, human (h)5-hydroxytryptamine (5-HT)2C… Expand
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Highly Cited
1997
Highly Cited
1997
Abstract We have identified subtype selective agonists, partial agonists and antagonists, which distinguish the human recombinant… Expand
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Highly Cited
1997
Highly Cited
1997
The phase-shifting capacity and thermoregulatory effects of a single oral administration at 18 h of melatonin (5 mg) or S-20098… Expand
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Highly Cited
1996
Highly Cited
1996
The present study determined first the dose-response (0.5 to 10 mg.kg-1) to daily oral administration of S-20098, a melatonin… Expand
Highly Cited
1996
Highly Cited
1996
We studied the effects of drugs related to melatonin on neuronal firing activity in the suprachiasmatic nucleus, intergeniculate… Expand
Highly Cited
1993
Highly Cited
1993
In human delayed sleep-phase syndrome (DSPS), sleep onset and wake times occur far later than normal. In the population, DSPS may… Expand