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Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system.Expand
Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis
Stress and glucocorticoid hormones regulate hippocampal neurogenesis, but the molecular mechanisms mediating these effects are poorly understood. Here we identify the glucocorticoid receptor (GR)Expand
Prenatal immune activation induces maturation-dependent alterations in the prefrontal GABAergic transcriptome.
Neuronal dysfunctions in the cortical GABAergic system have been widely documented in neuropsychiatric disorders with prenatal infectious etiologies, including schizophrenia. At least some of theseExpand
Mode of action of agomelatine: Synergy between melatonergic and 5-HT2C receptors
Abstract Objectives. The association between depression and circadian rhythm disturbances is well established and successful treatment of depressed patients is accompanied by restoration of circadianExpand
Neuronal plasticity: A link between stress and mood disorders
Although stress represents the major environmental element of susceptibility for mood disorders, the relationship between stress and disease remains to be fully established. In the present article weExpand
Chronic fluoxetine administration inhibits extracellular signal‐regulated kinase 1/2 phosphorylation in rat brain
Accumulating evidence indicates that antidepressants alter intracellular signalling mechanisms resulting in long‐term synaptic alterations which probably account for the delay in clinical action ofExpand
Glucocorticoid Receptor and FKBP5 Expression Is Altered Following Exposure to Chronic Stress: Modulation by Antidepressant Treatment
Major depression is thought to originate from the interaction between susceptibility genes and adverse environmental events, in particular stress. The hypothalamus–pituitary–adrenal (HPA) axis is theExpand
The serotonin–BDNF duo: Developmental implications for the vulnerability to psychopathology
Serotonin (5-HT) and brain-derived neurotrophin factor (BDNF) are known to modulate behavioral responses to stress and to mediate the therapeutic efficacy of antidepressant agents throughExpand
Chronic Duloxetine Treatment Induces Specific Changes in the Expression of BDNF Transcripts and in the Subcellular Localization of the Neurotrophin Protein
There is growing evidence that brain-derived neurotrophic factor (BDNF) can be relevant to mood disorders and that modulation of its biosynthesis following prolonged antidepressant treatment mayExpand
Reduced function of the serotonin transporter is associated with decreased expression of BDNF in rodents as well as in humans
In order to identify the molecular mechanisms that may contribute to the enhanced susceptibility to depression under serotonin transporter (SERT) dysfunction, we analyzed the expression ofExpand