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Distinct patterns of brain activity in young carriers of the APOE-ε4 allele
TLDR
The APOE ε4 allele modulates brain function decades before any clinical or neurophysiological expression of neurodegenerative processes and could be explained by differences in memory performance, brain morphology, or resting cerebral blood flow. Expand
Introduction to Systematic Reviews
TLDR
The advantages, as the authors see them, of systematic over narrative methodology are reprise here the advantages of systematic in approach. Expand
Cognitive deficits in depression: Possible implications for functional neuropathology
TLDR
A focus on the interactions between motivation, affect and cognitive function may allow greater understanding of the interplay between key aspect of the dorsal and ventral aspects of the prefrontal cortex in depression. Expand
Acute SSRI Administration Affects the Processing of Social Cues in Healthy Volunteers
TLDR
The results suggest that acute administration of antidepressant drugs may affect neural processes involved in the processing of social information, and may represent an early acute effect of SSRIs on social and emotional processing that is relevant to their therapeutic actions. Expand
Relapse prevention with antidepressant drug treatment in depressive disorders: a systematic review
TLDR
Continuing treatment with antidepressants in patients with depressive disorders who have responded to acute treatment reduced the odds of relapse by 70% and seemed to persist for up to 36 months, although most trials were of 12 months' duration, and so the evidence on longer-term treatment requires confirmation. Expand
Lithium toxicity profile: a systematic review and meta-analysis
TLDR
There is little evidence for a clinically significant reduction in renal function in most patients, and the risk of end-stage renal failure is low, but the balance of risks should be considered before lithium is withdrawn during pregnancy. Expand
Sustained attention deficit in bipolar disorder.
TLDR
Sustained attention deficit may represent a neuropsychological vulnerability marker for bipolar disorder, providing a focus for further understanding of the phenotype and analysis of the neuronal networks involved. Expand
Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy
TLDR
This article critically discusses the challenges and opportunities for improving cognition in individuals suffering from psychiatric disorders, highlighting the needs to characterize the cellular and cerebral circuits underpinning cognitive function and identify more effective treatments. Expand
Effect of acute antidepressant administration on negative affective bias in depressed patients.
TLDR
Antidepressant drug administration modulates emotional processing in depressed patients very early in treatment, before changes occur in mood and symptoms, suggesting a mechanism of action compatible with cognitive theories of depression. Expand
Risks of all‐cause and suicide mortality in mental disorders: a meta‐review
TLDR
The excess risks of mortality and suicide in all mental disorders justify a higher priority for the research, prevention, and treatment of the determinants of premature death in psychiatric patients. Expand
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