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Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
Cytokines are key regulatory mediators involved in the host response to immunological challenges, but also play a critical role in the communication between the immune and the central nervous system.Expand
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Social phobia: diagnosis and epidemiology, neurobiology and pharmacology, comorbidity and treatment.
Social phobia is a common disorder associated with significant psychosocial impairment, representing a substantial public health problem largely determined by the high prevalence, and the lifelongExpand
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Early maternal deprivation reduces the expression of BDNF and NMDA receptor subunits in rat hippocampus
It is well accepted that events that interfere with the normal program of neuronal differentiation and brain maturation may be relevant for the etiology of psychiatric disorders, setting the stageExpand
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Signaling Pathways Regulating Gene Expression, Neuroplasticity, and Neurotrophic Mechanisms in the Action of Antidepressants: A Critical Overview
Regulation of gene expression represents a major component in antidepressant drug action. The effect of antidepressant treatments on the function of cAMP-responsive element binding protein (CREB), aExpand
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New Insights into the Biology of Schizophrenia through the Mechanism of Action of Clozapine
Many studies have detected in the brain of schizophrenic patients various morphological and structural abnormalities in various regions and in particular in the cortical and limbic areas. TheseExpand
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Posttraumatic Stress Disorder: Diagnosis and Epidemiology, Comorbidity and Social Consequences, Biology and Treatment
Epidemiological studies clearly indicate that posttraumatic stress disorder (PTSD) is becoming a major health concern worldwide even if still poorly recognized and not well treated. PTSD commonlyExpand
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Mode of action of agomelatine: Synergy between melatonergic and 5-HT2C receptors
Abstract Objectives. The association between depression and circadian rhythm disturbances is well established and successful treatment of depressed patients is accompanied by restoration of circadianExpand
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Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes
Formation of reactive oxygen species and disfunction of the excitatory amino acid (EAA) system are thought to be key events in the development of neuronal injury in several acute and long-termExpand
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Neuronal plasticity: A link between stress and mood disorders
Although stress represents the major environmental element of susceptibility for mood disorders, the relationship between stress and disease remains to be fully established. In the present article weExpand
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Stress during development: Impact on neuroplasticity and relevance to psychopathology
Development represents a critical moment for shaping adult behavior and may set the stage to disease vulnerability later in life. There is now compelling evidence that stressful experiences duringExpand
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