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ALOX12 wt Allele

Known as: LOG12, 12S-LOX, Arachidonate 12-Lipoxygenase wt Allele 
Human ALOX12 wild-type allele is located in the vicinity of 17p13.1 and is approximately 15 kb in length. This allele, which encodes arachidonate 12… 
National Institutes of Health

Related topics

Related topics

7 relations
17p13.1Arachidonate 12-Lipoxygenase, 12S-TypeArachidonic Acid Metabolism PathwayLeukotriene Production

Broader (1)

ALOX12 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
PLATELETS AND THROMBOPOIESIS Platelet 12-LOX is essential for Fc g RIIa-mediated platelet activation
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet… 
2013
2013
[The role and clinical significance of 12-LOX passway in arachidonic acid metabolism induced by phospholipase Cgamma-2 in laryngeal squamous cell carcinoma].
OBJECTIVE To explore the expression of phospholipase Cgamma-2 (PLCgamma-2), lipoxygenase-12 (12-LOX) and arachidonic acid (AA) in… 
2012
2012
A novel interaction between 12-lipoxygenase and beta4 integrin plays a role in cancer progression
A DEFINED DOMAIN OF INTEGRIN SUBUNIT β4 DETERMINES INTERACTION WITH 12-LOX AND PLAYS A ROLE IN TUMOR PROGRESSION. by SANGEETA… 
2011
2011
Examination of 12-lipoxygenase (12-LOX) as a therapeutic target in non-small cell lung cancer (NSCLC): Mechanisms controlling survival and induction of apoptosis following selective inhibition.
7068 Background: Platelet-type 12-LOX is an arachidonic acid metabolising enzyme resulting in the formation of 12(S)-HETE, which… 
2011
2011
Abstract 2902: Phosphorylation of 12 lipoxygenase at Tyrosines 19 and 614 regulates its activity during beta4 integrin signaling
12-Lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid 12(S)-HETE, an eicosanoid implicated in… 
Highly Cited
2007
Highly Cited
2007
The Role of Arachidonic Acid and Its Metabolites in Insulin Secretion From Human Islets of Langerhans
The roles played by arachidonic acid and its cyclooxygenase (COX)-generated and lipoxygenase (LOX)-generated metabolites have… 
Highly Cited
2001
Highly Cited
2001
Selective oxygenation of the endocannabinoid 2-arachidonylglycerol by leukocyte-type 12-lipoxygenase.
The endogenous cannabinoid system appears to serve vascular, neurological, immunological, and reproductive functions. The… 
Highly Cited
2000
Highly Cited
2000
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
The platelet isoform of 12-lipoxygenase (12-LOX) is expressed in a variety of human tumors. 12-LOX metabolizes arachidonic acid… 
Highly Cited
1997
Highly Cited
1997
Renal oxygenases: differential contribution to vasoconstriction induced by ET-1 and ANG II.
In the rat isolated perfused kidney, 5,8,11,14-eicosatetraynoic acid, an inhibitor of all pathways of arachidonic acid (AA… 
Review
1997
Review
1997
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
We performed a detailed and comprehensive study of the involvement of tumor suppressor genes in human prostate cancer. We… 
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