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ALOX12 wt Allele

Known as: LOG12, 12S-LOX, Arachidonate 12-Lipoxygenase wt Allele 
Human ALOX12 wild-type allele is located in the vicinity of 17p13.1 and is approximately 15 kb in length. This allele, which encodes arachidonate 12… 
National Institutes of Health

Related topics

Related topics

7 relations
17p13.1Arachidonate 12-Lipoxygenase, 12S-TypeArachidonic Acid Metabolism PathwayLeukotriene Production

Broader (1)

ALOX12 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
PLATELETS AND THROMBOPOIESIS Platelet 12-LOX is essential for Fc g RIIa-mediated platelet activation
Platelets are essential in maintaining hemostasis following inflammation or injury to the vasculature. Dysregulated platelet… 
2014
2014
Inhibition of 12-lipoxygenase reduces platelet activation and prevents their mitogenic function
Abstract The aim of the present study was to investigate the role of 12-lipoxygenase (12-LOX) on platelet-induced airway smooth… 
2012
2012
A novel interaction between 12-lipoxygenase and beta4 integrin plays a role in cancer progression
A DEFINED DOMAIN OF INTEGRIN SUBUNIT β4 DETERMINES INTERACTION WITH 12-LOX AND PLAYS A ROLE IN TUMOR PROGRESSION. by SANGEETA… 
2011
2011
Examination of 12-lipoxygenase (12-LOX) as a therapeutic target in non-small cell lung cancer (NSCLC): Mechanisms controlling survival and induction of apoptosis following selective inhibition.
7068 Background: Platelet-type 12-LOX is an arachidonic acid metabolising enzyme resulting in the formation of 12(S)-HETE, which… 
2011
2011
Abstract 2902: Phosphorylation of 12 lipoxygenase at Tyrosines 19 and 614 regulates its activity during beta4 integrin signaling
12-Lipoxygenase (12-LOX) converts arachidonic acid to 12(S)-hydroxyeicosatetraenoic acid 12(S)-HETE, an eicosanoid implicated in… 
Highly Cited
2004
Highly Cited
2004
Blockade of 12-lipoxygenase expression protects cortical neurons from apoptosis induced by β-amyloid peptide
AbstractThe cyclo-oxygenase (COX) and lipoxygenase (LOX) pathways belong to the eicosanoid synthesis pathway, a major component… 
2002
2002
The future of cyclooxygenase-2 inhibitors and other inhibitors of the eicosanoid signal pathway in the prevention and therapy of lung cancer.
Recent advances in the understanding of the biology and molecular biology of lung cancer has provided targets for novel… 
Highly Cited
2000
Highly Cited
2000
Identification of 12-lipoxygenase interaction with cellular proteins by yeast two-hybrid screening.
The platelet isoform of 12-lipoxygenase (12-LOX) is expressed in a variety of human tumors. 12-LOX metabolizes arachidonic acid… 
Review
1997
Review
1997
Involvement of the multiple tumor suppressor genes and 12-lipoxygenase in human prostate cancer. Therapeutic implications.
We performed a detailed and comprehensive study of the involvement of tumor suppressor genes in human prostate cancer. We… 
1997
1997
Requirement for epidermal growth factor receptor tyrosine kinase and for 12-lipoxygenase activity in the expression of 12-lipoxygenase in human epidermoid carcinoma cells.
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