FAQ

ALOX12 gene

Known as: ARACHIDONATE 12-OXIDOREDUCTASE, platelet 12-LOX, 12LO 
This gene plays a role in oxidation of fatty acids.

Topic mentions per year

Topic mentions per year

1982-2018
051019822018

Related topics

Related topics

6 relations

Narrower (1)

ALOX12 wt Allele
Arachidonate 12-LipoxygenaseArachidonate 12-Lipoxygenase, 12S-TypeLeukotriene ProductionOxidation-Reduction
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Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
ALOX12 gene
Oxidation-Reduction
fatty acid metabolism
ALOX12 wt Allele
Arachidonate 12-Lipoxygenase, 12S-Type
Arachidonate 12-Lipoxygenase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency.
Haploinsufficiency of RUNX1 (also known as CBFA2/AML1) is associated with familial thrombocytopenia, platelet dysfunction, and… (More)
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2010
2010
ALOX12 gene is associated with the onset of natural menopause in white women.
OBJECTIVE Natural menopause is a key physiological event in a woman's life. Timing of menopause affects risk for many… (More)
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2008
2008
Induction of arachidonate 12-lipoxygenase (Alox15) in intestine of iron-deficient rats correlates with the production of biologically active lipid mediators.
To identify novel genes associated with iron metabolism, we performed gene chip studies in two models of iron deficiency: iron… (More)
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2006
2006
Human ALOX12, but not ALOX15, is associated with BMD in white men and women.
UNLABELLED The Alox15 gene was recently identified as a negative regulator of peak BMD in mice. Polymorphisms in human ALOX12… (More)
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2005
2005
Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity
Beta cell inflammation and cytokine-induced toxicity are central to autoimmune diabetes development. Lipid mediators generated… (More)
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2003
2003
Association of a new polymorphism in ALOX12 gene with bipolar disorder
Bipolar disorder (BPD) is characterised by episodes of excitement interspersed with periods of depression. The role of genetic… (More)
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2001
2001
Adenoviral delivery of a leukocyte-type 12 lipoxygenase ribozyme inhibits effects of glucose and platelet-derived growth factor in vascular endothelial and smooth muscle cells.
The lipoxygenase (LO) pathway has been implicated as an important mediator of chronic glucose and platelet-derived growth factor… (More)
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1994
1994
Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities.
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the… (More)
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1993
1993
Molecular cloning of a 12-lipoxygenase cDNA from rat brain.
A cDNA encoding an arachidonate 12-lipoxygenase from rat brain was obtained by polymerase chain reaction cloning. Primers… (More)
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1990
1990
Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes.
The complete amino acid sequence of arachidonate 12-lipoxygenase (EC 1.13.11.31) of porcine leukocytes was deduced by cloning and… (More)
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