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ALOX12 gene

Known as: ARACHIDONATE 12-OXIDOREDUCTASE, platelet 12-LOX, 12LO 
This gene plays a role in oxidation of fatty acids.
National Institutes of Health

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Related topics

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ALOX12 wt Allele
Arachidonate 12-LipoxygenaseArachidonate 12-Lipoxygenase, 12S-TypeLeukotriene ProductionOxidation-Reduction
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Papers overview

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2018
2018
An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury
Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy and validated pharmacological… Expand
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Highly Cited
2010
Highly Cited
2010
RUNX1/core binding factor A2 regulates platelet 12-lipoxygenase gene (ALOX12): studies in human RUNX1 haplodeficiency.
Haploinsufficiency of RUNX1 (also known as CBFA2/AML1) is associated with familial thrombocytopenia, platelet dysfunction, and… Expand
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Highly Cited
2006
Highly Cited
2006
Mechanisms Regulating Tumor Angiogenesis by 12-Lipoxygenase in Prostate Cancer Cells*
12-Lipoxygenase utilizes arachidonic acid to synthesize 12(S)-hydroperoxyeicosatetraenoic acid, which is converted to the end… Expand
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Highly Cited
2005
Highly Cited
2005
A Multifunctional Lipoxygenase with Fatty Acid Hydroperoxide Cleaving Activity from the Moss Physcomitrella patens*
A complex mixture of fatty acid-derived aldehydes, ketones, and alcohols is released upon wounding of the moss Physcomitrella… Expand
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Highly Cited
2005
Highly Cited
2005
Activation of 12-lipoxygenase in proinflammatory cytokine-mediated beta cell toxicity
Aims/hypothesisBeta cell inflammation and cytokine-induced toxicity are central to autoimmune diabetes development. Lipid… Expand
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Highly Cited
2000
Highly Cited
2000
Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase.
Angiogenesis, the formation of new capillaries from preexisting blood vessels, is a multistep, highly orchestrated process… Expand
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Highly Cited
1998
Highly Cited
1998
Platelet-type 12-lipoxygenase in a human prostate carcinoma stimulates angiogenesis and tumor growth.
Previously, we found a positive correlation between the expression of platelet-type 12-lipoxygenase (12-LOX) and the progression… Expand
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Highly Cited
1994
Highly Cited
1994
Oxidative modification of human lipoproteins by lipoxygenases of different positional specificities.
Cellular lipoxygenases have been implicated in foam cell formation during the early stages of atherogenesis. We studied the… Expand
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1992
1992
Selective expression of an arachidonate 12-lipoxygenase by pancreatic islet beta-cells.
The immunohistochemical distribution of arachidonate lipoxygenases in rat pancreas was characterized with specific polyclonal… Expand
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1990
1990
Cloning and sequence analysis of the cDNA for arachidonate 12-lipoxygenase of porcine leukocytes.
The complete amino acid sequence of arachidonate 12-lipoxygenase (EC 1.13.11.31) of porcine leukocytes was deduced by cloning and… Expand
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