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Arachidonate 12-Lipoxygenase, 12S-Type

Known as: EC 1.13.11.31, Platelet-Type Lipoxygenase 12, ALOX12 
Arachidonate 12-lipoxygenase, 12S-type (663 aa, ~76 kDa) is encoded by the human ALOX12 gene. This protein plays a role in both fatty acid oxidation… Expand
National Institutes of Health

Papers overview

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2018
2018
Neutrophil removal from inflammatory sites is regulated by lipid mediator signals between macrophages and neutrophils… Expand
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Highly Cited
2018
Highly Cited
2018
Hepatic ischemia–reperfusion (IR) injury is a common clinical issue lacking effective therapy and validated pharmacological… Expand
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Highly Cited
2017
Highly Cited
2017
Nitric oxide contributes to protection from tuberculosis. It is generally assumed that this protection is due to direct… Expand
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Highly Cited
2013
Highly Cited
2013
Aims/hypothesisChronic inflammation in type 2 diabetes is proposed to affect islets as well as insulin target organs. However… Expand
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Highly Cited
2012
Highly Cited
2012
RATIONALE Epigenetic changes may play a role in the occurrence of asthma-related phenotypes. OBJECTIVES To identify epigenetic… Expand
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Highly Cited
2012
Highly Cited
2012
Abberrant DNA methylation is one of the hallmarks of cancerogenesis. Our study aims to delineate differential DNA methylation in… Expand
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Highly Cited
2011
Highly Cited
2011
Lipoxygenase (ALOX) enzymes are implicated in both pro- and anti-atherogenic processes. The aim of this study was to investigate… Expand
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Highly Cited
2010
Highly Cited
2010
In this Phase 2 study, we evaluated the efficacy of combination of 5-azacitidine (AZA), valproic acid (VPA), and all-trans… Expand
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Highly Cited
2004
Highly Cited
2004
In the human colon, arachidonic acid is metabolized primarily by cyclooxygenase (COX) and arachidonate lipoxygenase (ALOX) to… Expand
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Highly Cited
2000
Highly Cited
2000
By using reverse transcription-polymerase chain reaction technology (RT-PCR) and Northern blot analysis, the tissue-specific mRNA… Expand
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