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Fetal programming of skeletal muscle development in ruminant animals.
TLDR
Strong experimental evidence indicates that Wingless and Int (Wnt)/beta-catenin signaling regulates MSC differentiation, and knowledge of this regulatory mechanism will allow the development of strategies to enhance muscle growth and marbling in offspring, especially in the setting of nutrient deficiency. Expand
Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring.
TLDR
It is demonstrated that a bout of maternal undernutrition during early to midgestation in sheep increased BW and fat deposition during adolescence and dysregulated glucose uptake in the absence of any change in birth weight. Expand
Maternal nutrient restriction affects properties of skeletal muscle in offspring
TLDR
It is demonstrated that the early to mid‐gestation period is important for skeletal muscle development, as impaired muscle development during this stage of gestation affects the number and composition of fibres in offspring which may lead to long‐term physiological consequences, including predisposition to obesity and diabetes. Expand
Developmental programming of the metabolic syndrome by maternal nutritional imbalance: how strong is the evidence from experimental models in mammals?
TLDR
Whether the metabolic syndrome can be reliably induced by the interventions made is assessed and the validity of the different species, diets, feeding regimes and end‐point measures used is discussed. Expand
A low maternal protein diet during pregnancy and lactation has sex‐ and window of exposure‐specific effects on offspring growth and food intake, glucose metabolism and serum leptin in the rat
TLDR
It is concluded that maternal protein restriction during either pregnancy and/or lactation alters postnatal growth, appetitive behaviour, leptin physiology, TG and cholesterol concentrations and modifies glucose metabolism and insulin resistance in a sex‐ and time window of exposure‐specific manner. Expand
Animal models that elucidate basic principles of the developmental origins of adult diseases.
TLDR
This review focuses on the use of animal models to evaluate exposures, mechanisms, and outcomes involved in developmental programming of hypertension, diabetes, obesity, and altered pituitary-adrenal function in offspring in later life. Expand
Efficacy of Dietary Arachidonic Acid Provided as Triglyceride or Phospholipid as Substrates for Brain Arachidonic Acid Accretion in Baboon Neonates
TLDR
It is estimated that about half of postnatal brain AA accretion is derived from dietary preformed AA in term baboon neonates consuming a formula with lipid composition similar to that of human milk. Expand
Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle.
TLDR
The data showed that myogenesis and the Wnt/beta-catenin signaling pathway were downregulated, which might be due to the upregulation of inflammatory IKK/NF-kappaB signaling pathways in fetal muscle of obese mothers. Expand
Sex differences in transgenerational alterations of growth and metabolism in progeny (F2) of female offspring (F1) of rats fed a low protein diet during pregnancy and lactation
TLDR
It is concluded that maternal protein restriction adversely affects glucose and insulin metabolism of male and female F2 offspring in a manner specific to sex and developmental time window during their mother's fetal and neonatal development. Expand
Why primate models matter
TLDR
Key areas in biomedicine where primate models have been, and continue to be, essential for advancing fundamental knowledge in biomedical and biological research are reviewed. Expand
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