ALK protein, human

Known as: ALK, CD246 Antigen, CD246 protein, human 
ALK tyrosine kinase receptor (1620 aa, ~176 kDa) is encoded by the human ALK gene. This protein is involved in ligand binding, tyrosine… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1976-2017
05010019762017

Papers overview

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Highly Cited
2014
Highly Cited
2014
BACKGROUND Chromosomal rearrangements of the gene encoding ROS1 proto-oncogene receptor tyrosine kinase (ROS1) define a distinct… (More)
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Highly Cited
2014
Highly Cited
2014
Targeted cancer therapies have produced substantial clinical responses, but most tumors develop resistance to these drugs. Here… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND ALK gene rearrangement defines a new molecular subtype of non-small-cell lung cancer (NSCLC). In a recent phase 1… (More)
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Highly Cited
2010
Highly Cited
2010
The ALK kinase inhibitor crizotinib (PF-02341066) is clinically effective in patients with ALK-translocated cancers, but its… (More)
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Highly Cited
2008
Highly Cited
2008
Neuroblastoma, a tumour derived from the peripheral sympathetic nervous system, is one of the most frequent solid tumours in… (More)
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Highly Cited
2008
Highly Cited
2008
Neuroblastoma, an embryonal tumour of the peripheral sympathetic nervous system, accounts for approximately 15% of all deaths due… (More)
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Highly Cited
2004
Highly Cited
2004
During synapse formation, specialized subcellular structures develop at synaptic junctions in a tightly regulated fashion. Cross… (More)
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Highly Cited
2003
Highly Cited
2003
The secreted protein Jelly belly (Jeb) is required for an essential signalling event in Drosophila muscle development. In the… (More)
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Highly Cited
2000
Highly Cited
2000
Inflammatory myofibroblastic tumors (IMTs) are neoplastic mesenchymal proliferations featuring an inflammatory infiltrate… (More)
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Highly Cited
1997
Highly Cited
1997
The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation… (More)
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