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ALK wt Allele

Known as: ALK, Anaplastic Lymphoma Kinase (Ki-1) wt Allele 
Human ALK wild-type allele is located within 2p23 and is approximately 729 kb in length. This allele, which encodes ALK tyrosine kinase receptor… 
National Institutes of Health

Related topics

Related topics

12 relations
2p23ALK protein, humanAdenocarcinoma of lung (disorder)Anaplastic Large Cell Lymphoma, ALK-Positive

Broader (1)

ALK gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2018
Review
2018
Clinical and Translational Implications of RET Rearrangements in Non-Small Cell Lung Cancer.
Review
2018
Review
2018
The Incidence of Brain Metastases in Stage IV ROS1‐Rearranged Non–Small Cell Lung Cancer and Rate of Central Nervous System Progression on Crizotinib
Review
2017
Review
2017
Genetic susceptibility to neuroblastoma.
Review
2016
Review
2016
Morphologic Features of ALK-negative Anaplastic Large Cell Lymphomas With DUSP22 Rearrangements
Systemic anaplastic large cell lymphomas (ALCLs) are classified into ALK-positive and ALK-negative types. We recently reported… 
Highly Cited
2015
Highly Cited
2015
Clinical, Histopathologic, and Genomic Features of Spitz Tumors With ALK Fusions
Activating kinase fusions have recently been described as early oncogenic events that are mutually exclusive with HRAS and BRAF… 
Highly Cited
2014
Highly Cited
2014
Emergence of new ALK mutations at relapse of neuroblastoma.
PURPOSE In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of… 
Highly Cited
2012
Highly Cited
2012
Worse Disease-Free Survival in Never-Smokers with ALK+ Lung Adenocarcinoma
Introduction: The EML4–anaplastic lymphoma kinase (ALK) translocation is a recognized oncogenic driver in non-small cell lung… 
Highly Cited
2011
Highly Cited
2011
Midkine and Alk signaling in sympathetic neuron proliferation and neuroblastoma predisposition
Neuroblastoma (NB) is the most common extracranial solid tumor in childhood and arises from cells of the developing… 
Highly Cited
2000
Highly Cited
2000
Expression of the ALK tyrosine kinase gene in neuroblastoma.
Highly Cited
1998
Highly Cited
1998
Detection of the t(2;5)‐associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals
The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK… 
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