ALK wt Allele

Known as: ALK, Anaplastic Lymphoma Kinase (Ki-1) wt Allele 
Human ALK wild-type allele is located within 2p23 and is approximately 729 kb in length. This allele, which encodes ALK tyrosine kinase receptor… (More)
National Institutes of Health

Papers overview

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Highly Cited
2014
Highly Cited
2014
PURPOSE In neuroblastoma, the ALK receptor tyrosine kinase is activated by point mutations. We investigated the potential role of… (More)
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2014
2014
Mutations in the ALK tyrosine kinase receptor gene represent important therapeutic targets in neuroblastoma, yet their clinical… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE The diagnostic test for ALK rearrangement in non-small-cell lung cancer (NSCLC) for crizotinib treatment is currently… (More)
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Highly Cited
2013
Highly Cited
2013
INTRODUCTION A number of novel therapies are under investigation in relapsed or refractory peripheral T-cell lymphoma (PTCL… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND The discovery of distinct subsets of nonsmall cell lung cancer (NSCLC) characterized by activation of driver oncogenes… (More)
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Highly Cited
2012
Highly Cited
2012
INTRODUCTION The EML4-anaplastic lymphoma kinase (ALK) translocation is a recognized oncogenic driver in non-small cell lung… (More)
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2012
2012
PURPOSE Approximately 3% to 7% of non-small cell lung cancers (NSCLC) harbor an ALK fusion gene, thus defining a tumor group that… (More)
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Highly Cited
2011
Highly Cited
2011
A subset (1% to 5%) of non-small-cell lung carcinomas harbors the EML4-ALK fusion gene. Data from previous studies on the… (More)
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2011
2011
Mutations in the kinase domain of ALK (anaplastic lymphoma kinase) have recently been shown to be important for the progression… (More)
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Highly Cited
2000
Highly Cited
2000
ALK (anaplastic lymphoma kinase) is a tyrosine kinase receptor, expressed as part of the chimeric NPM-ALK protein, in anaplastic… (More)
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