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ALK gene

Known as: Anaplastic Lymphoma Kinase (Ki-1) Gene, ANAPLASTIC LYMPHOMA KINASE, ALK/NPM1 FUSION GENE 
This gene is involved in brain development and neuronal specificity.
National Institutes of Health

Related topics

Related topics

47 relations
ALK protein, humanAbdominal Inflammatory Myofibroblastic TumorAdenocarcinoma of lung (disorder)Anaplastic Large Cell Lymphoma, ALK-Positive

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ALK wt Allele

Papers overview

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Highly Cited
2012
Highly Cited
2012
Histologic subtypes, immunohistochemistry, FISH or molecular screening for the accurate diagnosis of ALK-rearrangement in lung cancer: a comprehensive study of Caucasian non-smokers.
Highly Cited
2008
Highly Cited
2008
C. elegans Anaplastic Lymphoma Kinase Ortholog SCD-2 Controls Dauer Formation by Modulating TGF-β Signaling
Highly Cited
2007
Highly Cited
2007
Oncogenic tyrosine kinase NPM/ALK induces activation of the MEK/ERK signaling pathway independently of c-Raf
The mechanisms of cell transformation mediated by the highly oncogenic, chimeric NPM/ALK tyrosine kinase remain only partially… 
Highly Cited
2005
Highly Cited
2005
Inhibition of ALK enzymatic activity in T-cell lymphoma cells induces apoptosis and suppresses proliferation and STAT3 phosphorylation independently of Jak3
Aberrant expression of the ALK tyrosine kinase as a chimeric protein with nucleophosmin (NPM) and other partners plays a key role… 
Highly Cited
2003
Highly Cited
2003
Vav-promoter regulated oncogenic fusion protein NPM-ALK in transgenic mice causes B-cell lymphomas with hyperactive Jun kinase
Anaplastic large-cell lymphoma is associated with a chromosomal translocation generating an oncogenic fusion protein: the… 
Highly Cited
2003
Highly Cited
2003
Constitutive activation of Jak2 contributes to proliferation and resistance to apoptosis in NPM/ALK-transformed cells.
2003
2003
The oncogenic fusion protein nucleophosmin–anaplastic lymphoma kinase (NPM–ALK) induces two distinct malignant phenotypes in a murine retroviral transplantation model
A t(2;5) (p23;q35) chromosomal translocation can be found in a high percentage of anaplastic large-cell lymphomas (ALCL). This… 
Highly Cited
1998
Highly Cited
1998
Detection of the t(2;5)‐associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals
The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK… 
Highly Cited
1998
Highly Cited
1998
Characterization of t(2;5) reciprocal transcripts and genomic breakpoints in CD30+ cutaneous lymphoproliferations.
NPM-ALK chimeric transcripts, encoded by the t(2;5), lead to an aberrant expression of ALK by CD30+ systemic lymphomas. To… 
Highly Cited
1974
Highly Cited
1974
Covalent structure of calf-thymus ALK-histone.
Highly purified calf thymus ALK-histone (histone rich in alanine, lecine and lysine) was isolated from F2a2 histone fraction by… 
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