Skip to search formSkip to main contentSkip to account menu

ALK gene

Known as: Anaplastic Lymphoma Kinase (Ki-1) Gene, ANAPLASTIC LYMPHOMA KINASE, ALK/NPM1 FUSION GENE 
This gene is involved in brain development and neuronal specificity.
National Institutes of Health

Related topics

Related topics

47 relations
ALK protein, humanAbdominal Inflammatory Myofibroblastic TumorAdenocarcinoma of lung (disorder)Anaplastic Large Cell Lymphoma, ALK-Positive

Narrower (1)

ALK wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Abstract 2136: Entrectinib is effective against the gatekeeper and other emerging resistance mutations in NTRK-, ROS1- and ALK- rearranged cancers
Gene rearrangements involving NTRK1, NTRK2, NTRK3, ROS1 and ALK result in oncogenic fusion proteins that have been identified in… 
2015
2015
Identi fi cation of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB 4 transcripts
Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts Irene Scarfò,* Elisa… 
Review
2015
Review
2015
[Molecular mechanisms of targeted drug resistance in lung cancer and its therapeutic strategy].
Several driver oncogenes, including EGFR mutations and ALK rearrangement, have been identified in lung cancer. The EGFR tyrosine… 
2015
2015
[Expression of microRNA in ALK-negative anaplastic large cell lymphoma and CD30-positive peripheral T cell lymphoma, not otherwise specified].
OBJECTIVE To study the role of microRNAs (miRNAs) in ALK-negative anaplastic large cell lymphoma and CD30 positive peripheral T… 
2015
2015
Using the Second-Generation ALK Inhibitor AP 26113 in Human NPM-ALK – Positive Anaplastic Large Cell Lymphoma
ALK is a tyrosine kinase receptor involved in a broad range of solid and hematologic tumors. Among 70% to 80% of ALKþ anaplastic… 
2014
2014
Zalecenia metodyczne dotyczące oceny mutacji genu EGFR oraz rearanżacji genu ALK w kwalifikacji chorych na niedrobnokomórkowego raka płuca do terapii ukierunkowanych molekularnie
Badania molekularne mające na celu wykrycie mutacji genu EGFR i rearanzacji genu ALK wykonuje sie rutynowo w zaawansowanym… 
2013
2013
Close Neighbours on Chromosome 2 the ALK and MYCN Genes. Implications for Targeted Therapeutics in Neuroblastoma
Neuroblastoma is a neural crest-derived embryonal malignancy of the postganglionic sympathetic division of the peripheral… 
2010
2010
Frequencies of ALK and ROS in NSCLC FFPE tumor samples utilizing a highly specific immunohistochemistry-based assay and FISH analysis.
10536 Background: Receptor tyrosine kinases ALK and ROS are expressed as oncogenic fusion proteins in approximately 2%-5% of all… 
1999
1999
NPM/ALK rearrangements in indolent cutaneous lesions
The (2;5)(p23;q35) translocation, which results in the fusion of the NPM (nucleophosmin) gene on chromosome 5q35 with the novel… 
Highly Cited
1974
Highly Cited
1974
Covalent structure of calf-thymus ALK-histone.
Highly purified calf thymus ALK-histone (histone rich in alanine, lecine and lysine) was isolated from F2a2 histone fraction by…