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ALK gene

Known as: Anaplastic Lymphoma Kinase (Ki-1) Gene, ANAPLASTIC LYMPHOMA KINASE, ALK/NPM1 FUSION GENE 
This gene is involved in brain development and neuronal specificity.
National Institutes of Health

Related topics

Related topics

47 relations
ALK protein, humanAbdominal Inflammatory Myofibroblastic TumorAdenocarcinoma of lung (disorder)Anaplastic Large Cell Lymphoma, ALK-Positive

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ALK wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2020
Review
2020
O81 IMpower110: interim overall survival (OS) analysis of a phase III study of atezolizumab (ATEZO) monotherapy vs platinum-based chemotherapy (CHEMO) as first-line (1L) treatment in PD-L1–selected…
Background PD-L1/PD-1 inhibitors (CPI) as monotherapy or in combination with platinum-based doublet chemo (± bevacizumab) are 1L… 
2016
2016
High concordance of ALK rearrangement between primary tumor and paired metastatic lymph node in patients with lung adenocarcinoma.
BACKGROUND Lung cancer has heterogeneous features. It remains unclear whether ALK rearrangement was distributed heterogeneously… 
2016
2016
Abstract 2136: Entrectinib is effective against the gatekeeper and other emerging resistance mutations in NTRK-, ROS1- and ALK- rearranged cancers
Gene rearrangements involving NTRK1, NTRK2, NTRK3, ROS1 and ALK result in oncogenic fusion proteins that have been identified in… 
2015
2015
Identi fi cation of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB 4 transcripts
Identification of a new subclass of ALK-negative ALCL expressing aberrant levels of ERBB4 transcripts Irene Scarfò,* Elisa… 
2013
2013
ALK-Positive Anaplastic Large Cell Lymphoma
Anaplastic lymphoma kinase–positive (ALK+) anaplastic large cell lymphoma (ALCL) is a CD30+ T-cell lymphoma with a T- or null… 
2010
2010
Frequencies of ALK and ROS in NSCLC FFPE tumor samples utilizing a highly specific immunohistochemistry-based assay and FISH analysis.
10536 Background: Receptor tyrosine kinases ALK and ROS are expressed as oncogenic fusion proteins in approximately 2%-5% of all… 
2009
2009
Upregulation of the CDC25A phosphatase downstream of the NPM/ALK oncogene participates in anaplastic large cell lymphoma enhanced proliferation
Here, we demonstrate that the expression of the dual specificity phosphatase CDC25A, a key regulator of cell cycle progression… 
2006
2006
GENE EXPRESSION PROFILING OF SYSTEMIC ANAPLASTIC LARGE CELL LYMPHOMA REVEALS DIFFERENCES DEPENDING ON ALK STATUS AND TWO DISTINCT MORPHOLOGICAL ALK SUBTYPES
LL, EE and GD designed research; MMD, FS and SG performed research; LB and PG collected data; ADR, DR, EE and LL analyzed data… 
Highly Cited
1998
Highly Cited
1998
Detection of the t(2;5)‐associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals
The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK… 
Highly Cited
1974
Highly Cited
1974
Covalent structure of calf-thymus ALK-histone.
Highly purified calf thymus ALK-histone (histone rich in alanine, lecine and lysine) was isolated from F2a2 histone fraction by… 
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