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Negative regulation of the human apolipoprotein A-I promoter by fibrates can be attenuated by the interaction of the peroxisome proliferator-activated receptor with its response element.
- N. Vu-dac, K. Schoonjans, B. Laine, J. Fruchart, J. Auwerx, B. Staels
- Medicine, Biology
- The Journal of biological chemistry
- 9 December 1994
The data suggest that certain peroxisome proliferators can reduce the expression of the apoA-I promoter in a PPAR-independent fashion, through modulation of factors interacting with sequences localized between -41 and +91 of the APO-I gene transcription initiation site. Expand
Negative regulation of human fibrinogen gene expression by peroxisome proliferator-activated receptor alpha agonists via inhibition of CCAAT box/enhancer-binding protein beta.
It is observed that the anti-inflammatory action of PPAR alpha is not restricted to fibrinogen but also applies to other acute phase genes containing a C/EBP response element; it also occurs under conditions in which the stimulating action of IL-6 is potentiated by dexamethasone. Expand
Negative Regulation of Human Fibrinogen Gene Expression by Peroxisome Proliferator-activated Receptor α Agonists via Inhibition of CCAAT Box/Enhancer-binding Protein β*
- P. Gervois, N. Vu-dac, +7 authors B. Staels
- The Journal of Biological Chemistry
- 7 September 2001
It is observed that the anti-inflammatory action of PPARα is not restricted to fibrinogen but also applies to other acute phase genes containing a C/EBP response element; it also occurs under conditions in which the stimulating action of IL-6 is potentiated by dexamethasone. Expand
A missense mutation in hepatocyte nuclear factor-4 alpha, resulting in a reduced transactivation activity, in human late-onset non-insulin-dependent diabetes mellitus.
- E. Hani, L. Suaud, +10 authors P. Froguel
- Medicine, Biology
- The Journal of clinical investigation
- 1 February 1998
A missense mutation, resulting in a valine-to-isoleucine substitution at codon 393 in a single family is consistent with this mutation contributing to the insulin secretory defect observed in this family. Expand
Hepatocyte nuclear factor 4 alpha isoforms originated from the P1 promoter are expressed in human pancreatic beta-cells and exhibit stronger transcriptional potentials than P2 promoter-driven…
The results highlight that expression of P1 promoter-driven isoforms is important in the control of pancreatic beta-cell function and highlight the importance of the activation function module AF-1. Expand
Cloning and sequencing of cDNAs encoding the human hepatocyte nuclear factor 4 indicate the presence of two isoforms in human liver.
Hepatocyte nuclear factor 4 (HNF-4) is a key transcription factor involved in the specific expression of many genes in liver and intestine. Sequences of cDNAs coding for HNF-4 have been established… Expand
Characterization of the chromosomal protein MC1 from the thermophilic archaebacterium Methanosarcina sp. CHTI 55 and its effect on the thermal stability of DNA.
The studies indicate that one molecule of protein MC1 protects eight base pairs of DNA, which is close to the normal level for a deoxyribonucleoprotein complex. Expand
Complete amino-acid sequences of DNA-binding proteins HU-1 and HU-2 from Escherichia coli.
- B. Laine, D. Kmiécik, P. Sautière, G. Biserte, M. Cohen-Solal
- Biology, Medicine
- European journal of biochemistry
- 1 February 1980
The results presented in this paper confirm the amino- terminal and carboxy-terminal sequences of the dimer HU reported previously and confirm the sequence homology could be established between the proteins HU-1 and H U-2 and any one of the five histones from different eukaryotes. Expand
Transgenic rabbits expressing human apolipoprotein A-I in the liver.
- N. Duverger, C. Viglietta, +9 authors P. Denèfie
- Biology, Medicine
- Arteriosclerosis, thrombosis, and vascular…
- 1 December 1996
These rabbits will be an extremely useful model for the evaluation of the effect of increased hepatic apo A-I expression on atherosclerosis. Expand
Hepatocyte Nuclear Factor 4α enhances the Hepatocyte Nuclear Factor 1α‐mediated activation of transcription
It is shown that HNF4alpha enhances the transcriptional activity of H NF1alpha in a DNA binding independent manner, thus indicating that it behaves as a HNF1alpha coactivator. Expand