• Publications
  • Influence
H2A.Z facilitates access of active and repressive complexes to chromatin in embryonic stem cell self-renewal and differentiation.
It is proposed that H2A.Z mediates both self-renewal and differentiation of embryonic stem cells by acting as a general facilitator that generates access for a variety of complexes, both activating and repressive. Expand
The structure of histone H1 and its location in chromatin
On the basis of their primary structure, the lysine-rich histones are a unified family of proteins that are protected from trypsin digestion in chromatin and corresponds to the segment of highest sequence conservation. Expand
A direct link between core histone acetylation and transcriptionally active chromatin.
The results demonstrate directly that transcriptionally active genes carry acetylated core histones in chromatin fragments fractions from the nuclei of 15‐day chicken embryo erythrocytes. Expand
Solution structure of a DNA-binding domain from HMG1.
Inspection of the fold shows that the majority of conserved residue positions in the HMG box family are those involved in maintaining the tertiary structure and thus all homologous HMG boxes probably have essentially the same fold. Expand
Core histone hyperacetylation co‐maps with generalized DNase I sensitivity in the chicken beta‐globin chromosomal domain.
The distribution of core histone acetylation across the chicken beta‐globin locus has been mapped in 15 day chicken embryo erythrocytes by immunoprecipitation of mononucleosomes with an antibodyExpand
Interpreting protein/DNA interactions: distinguishing specific from non-specific and electrostatic from non-electrostatic components
It is shown that although this electrostatic component provides the majority of the Gibbs energy of complex formation and does not depend on the DNA sequence, the salt-independent part of the Edwards energy—usually regarded as non-electrostatic—is sequence specific. Expand
The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken
A affinity-purified antibodies against the N-terminal region of H2A.Z are used in native chromatin immmuno-precipitation experiments with mononucleosomes from three chicken cell types to resolve an apparent dichotomy in its reported links to gene expression and preventing the spread of heterochromatin in yeast and mammals. Expand
Roles of H1 domains in determining higher order chromatin structure and H1 location.
The precise placement of the H1 molecule (globular domain) with respect to the nucleosome is shown to be influenced by the "tail" domains of both H1 and the core histones, and this function is primarily controlled by the COOH-terminal domain of the molecule. Expand
Targeted and Extended Acetylation of Histones H4 and H3 at Active and Inactive Genes in Chicken Embryo Erythrocytes*
The targeted acetylation of histones H3 and H4 at the GAPDH andCA genes is consistent with a role in transcriptional initiation and implies that transcriptional elongation does not necessarily require hyperacetylation. Expand
Thyroid hormone‐regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor
Thyroid hormone can regulate enhancer blocking, thereby providing a new property for what was previously thought to be constitutive enhancer shielding by CTCF. Expand