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AKR1C1 protein, human

Known as: Type II 3-Alpha-Hydroxysteroid Dehydrogenase, aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase), human, Chlordecone Reductase Homolog HAKRC 
Aldo-keto reductase family 1 member C1 (323 aa, ~37 kDa) is encoded by the human AKR1C1 gene. This protein is involved in the conversion of… 
National Institutes of Health

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10 relations
AKR1C1 geneAKR1C2 protein, humanAKR1C3 protein, humanCholesterol Homeostasis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Metabolism and distribution of benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) in human lung cells by liquid chromatography tandem mass spectrometry: detection of an adenine B[a]P-7,8-dione adduct.
Benzo[a]pyrene-7,8-dione (B[a]P-7,8-dione) is produced in human lung cells by the oxidation of (±)-B[a]P-7,8-trans-dihydrodiol… 
Highly Cited
2003
Highly Cited
2003
An aldose reductase with 20 alpha-hydroxysteroid dehydrogenase activity is most likely the enzyme responsible for the production of prostaglandin f2 alpha in the bovine endometrium.
Prostaglandins are important regulators of reproductive function. In particular, prostaglandin F2 alpha (PGF(2 alpha)) is… 
1997
1997
Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79…
Polycyclic aromatic hydrocarbons require metabolic activation in order to exert their biological activity initiated by DNA… 
1997
1997
Characterization of DNA adducts formed by the four configurationally isomeric 5,6-dimethylchrysene 1,2-dihydrodiol 3,4-epoxides.
The DNA adducts formed from the racemic syn and anti dihydrodiol epoxides of 5,6-dimethylchrysene were characterized through… 
1995
1995
Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity.
The prostaglandin-E2 9-reductase (PGE2 9-reductase) activity in the corpus luteum of rabbits corresponds to a cytosolic, NADPH… 
1993
1993
Detection of the major DNA adducts of benzo[j]fluoranthene in mouse skin: nonclassical dihydrodiol epoxides.
Studies have demonstrated that the metabolic activation of benzo[j]fluoranthene (B[j]F) to a genotoxic agent proceeds through the… 
Highly Cited
1989
Highly Cited
1989
Dioxygenolytic cleavage of aryl ether bonds: 1,10-dihydro-1,10-dihydroxyfluoren-9-one, a novel arene dihydrodiol as evidence for angular dioxygenation of dibenzofuran.
Two dibenzofuran degrading bacteria, Brevibacterium strain DPO 1361 and strain DPO 220, were found to utilize fluorene as sole… 
Highly Cited
1981
Highly Cited
1981
Direct stimulation of ovarian progesterone-metabolizing enzyme by gonadotropin-releasing hormone in cultured granulosa cells.
Highly Cited
1979
Highly Cited
1979
Reduction of benzo(a)pyrene mutagenicity by dihydrodiol dehydrogenase
THE enigma of how inert chemicals can exert potent mutagenic, carcinogenic, allergenic and cytotoxic effects has been much… 
1969
1969
Influence of transcortin and albumin on the rate of reduction of progesterone on human placental 20-alpha-hydroxysteroid dehydrogenase.
Purified human placental 20α-hydroxysteroid dehydrogenase was incubated with progesterone-4-14C in the presence or absence of… 
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