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AKR1C2 protein, human

Known as: aldo-keto reductase family 1, member C2 protein, human, Aldo-Keto Reductase Family 1 Member C2, Type III 3-Alpha-Hydroxysteroid Dehydrogenase 
Aldo-keto reductase family 1 member C2 (323 aa, ~37 kDa) is encoded by the human AKR1C2 gene. This protein plays a role in the metabolism of steroid… Expand
National Institutes of Health

Related topics

Related topics

12 relations
AKR1C1 protein, humanAKR1C2 geneAKR1C3 protein, humanAdrenal Glands
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Broader (1)

Hydroxysteroid Dehydrogenases

Papers overview

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Highly Cited
2008
Highly Cited
2008
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells
Polycyclic aromatic hydrocarbons (PAHs) are tobacco carcinogens implicated in the causation of human lung cancer. Metabolic… Expand
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Highly Cited
2008
Highly Cited
2008
Oxidation of PAH trans-dihydrodiols by human aldo-keto reductase AKR1B10.
AKR1B10 has been identified as a potential biomarker for human nonsmall cell lung carcinoma and as a tobacco exposure and… Expand
Highly Cited
2006
Highly Cited
2006
Study of Biochemical Pathways and Enzymes Involved in Pyrene Degradation by Mycobacterium sp. Strain KMS
ABSTRACT Pyrene degradation is known in bacteria. In this study, Mycobacterium sp. strain KMS was used to study the metabolites… Expand
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2004
2004
METABOLISM AND DISPOSITION OF CALCIMIMETIC AGENT CINACALCET HCL IN HUMANS AND ANIMAL MODELS
The metabolism and disposition of calcimimetic agent cinacalcet HCl was examined after a single oral administration to mice, rats… Expand
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Highly Cited
2000
Highly Cited
2000
Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction.
A resistant descendant of the human stomach carcinoma cell line EPG85-257 was selected in the presence of increasing… Expand
1997
1997
Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79…
Polycyclic aromatic hydrocarbons require metabolic activation in order to exert their biological activity initiated by DNA… Expand
Highly Cited
1996
Highly Cited
1996
Site-directed mutagenesis of conserved amino acids in the alpha subunit of toluene dioxygenase: potential mononuclear non-heme iron coordination sites.
The terminal oxygenase component of toluene dioxygenase from Pseudomonas putida F1 is an iron-sulfur protein (ISP(TOL)) that… Expand
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Highly Cited
1993
Highly Cited
1993
Monkey 3-deoxyglucosone reductase: tissue distribution and purification of three multiple forms of the kidney enzyme that are identical with dihydrodiol dehydrogenase, aldehyde reductase, and aldose…
3-Deoxyglucosone (3DG) is a reactive intermediate in the glucose-mediated cross-linking of proteins. An enzyme catalyzing the… Expand
1982
1982
Tumour initiating activity of dihydrodiols of benzo[b]fluoranthene, benzo[j]fluoranthene, and benzo[k]fluoranthene.
The tumor initiating activities on mouse skin of benzo[b]fluoranthene, (B[b]F), benzo[j]fluoranthene (B[j]F), benzo[k… Expand
1977
1977
Purification and properties of cis-toluene dihydrodiol dehydrogenase from Pseudomonas putida.
The purification of (+)-cis-1(S),2(R)-dihydroxy-3-methylcyclohexa-3,5-diene dehydrogenase from cells of Pseudomonas putida grown… Expand
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