Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

AKR1C2 protein, human

Known as: aldo-keto reductase family 1, member C2 protein, human, Aldo-Keto Reductase Family 1 Member C2, Type III 3-Alpha-Hydroxysteroid Dehydrogenase 
Aldo-keto reductase family 1 member C2 (323 aa, ~37 kDa) is encoded by the human AKR1C2 gene. This protein plays a role in the metabolism of steroid… Expand
National Institutes of Health

Related topics

Related topics

12 relations
AKR1C1 protein, humanAKR1C2 geneAKR1C3 protein, humanAdrenal Glands
Expand

Broader (1)

Hydroxysteroid Dehydrogenases

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Polymorphic Variants of SCN1A and EPHX1 Influence Plasma Carbamazepine Concentration, Metabolism and Pharmacoresistance in a Population of Kosovar Albanian Epileptic Patients
AIM The present study aimed to evaluate the effects of gene variants in key genes influencing pharmacokinetic and pharmacodynamic… Expand
  • table 1
  • figure 1
  • figure 2
  • figure 3
  • table 2
Is this relevant?
2013
2013
MicroRNA-29a regulates the benzo[a]pyrene dihydrodiol epoxide-induced DNA damage response through Cdc7 kinase in lung cancer cells
Cdc7 kinase is a key regulator of DNA replication and has an important role in the cellular DNA damage response by controlling… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2012
2012
Aldo-keto reductases protect lung adenocarcinoma cells from the acute toxicity of B[a]P-7,8-trans-dihydrodiol.
Tobacco smoke exposure stimulates the expression of genes that are likely to be involved in the metabolism of its combustion… Expand
Is this relevant?
2008
2008
Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells.
Polycyclic aromatic hydrocarbons (PAHs) are tobacco carcinogens implicated in the causation of human lung cancer. Metabolic… Expand
  • figure 1
  • figure 2
  • figure 4
  • figure 3
Is this relevant?
Highly Cited
2006
Highly Cited
2006
Study of biochemical pathways and enzymes involved in pyrene degradation by Mycobacterium sp. strain KMS.
Pyrene degradation is known in bacteria. In this study, Mycobacterium sp. strain KMS was used to study the metabolites produced… Expand
  • figure 1
  • figure 2
  • figure 3
  • table 1
  • figure 4
Is this relevant?
2004
2004
Metabolism and disposition of calcimimetic agent cinacalcet HCl in humans and animal models.
The metabolism and disposition of calcimimetic agent cinacalcet HCl was examined after a single oral administration to mice, rats… Expand
  • table 1
  • table 2
  • table 3
  • table 4
  • figure 1
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Development of daunorubicin resistance in tumour cells by induction of carbonyl reduction.
A resistant descendant of the human stomach carcinoma cell line EPG85-257 was selected in the presence of increasing… Expand
Is this relevant?
1997
1997
Metabolic activation of the (+)-S,S- and (-)-R,R-enantiomers of trans-11,12-dihydroxy-11,12-dihydrodibenzo[a,l]pyrene: stereoselectivity, DNA adduct formation, and mutagenicity in Chinese hamster V79…
Polycyclic aromatic hydrocarbons require metabolic activation in order to exert their biological activity initiated by DNA… Expand
Is this relevant?
Highly Cited
1996
Highly Cited
1996
Site-directed mutagenesis of conserved amino acids in the alpha subunit of toluene dioxygenase: potential mononuclear non-heme iron coordination sites.
The terminal oxygenase component of toluene dioxygenase from Pseudomonas putida F1 is an iron-sulfur protein (ISP(TOL)) that… Expand
  • figure 1
  • table 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
1977
1977
Purification and properties of cis-toluene dihydrodiol dehydrogenase from Pseudomonas putida.
The purification of (+)-cis-1(S),2(R)-dihydroxy-3-methylcyclohexa-3,5-diene dehydrogenase from cells of Pseudomonas putida grown… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE