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Identification of BCRP as transporter of benzo[a]pyrene conjugates metabolically formed in Caco-2 cells and its induction by Ah-receptor agonists.
There is strong evidence that BCRP is an important part of the intestinal barrier protecting the body from food-associated contaminants such as the carcinogen BP. Expand
Biomonitoring of polycyclic aromatic hydrocarbons in human urine.
  • J. Jacob, A. Seidel
  • Chemistry, Medicine
  • Journal of chromatography. B, Analytical…
  • 5 October 2002
The role of these PAH metabolites as established biomarkers and also more recent developments of PAH biomonitoring are discussed. Expand
Biomonitoring of polycyclic aromatic compounds in the urine of mining workers occupationally exposed to diesel exhaust.
Diesel exposure led to an increase of PAH metabolism in the workers examined, most probably by an induction of cytochrome P450. Expand
Differences in the catalytic efficiencies of allelic variants of glutathione transferase P1-1 towards carcinogenic diol epoxides of polycyclic aromatic hydrocarbons.
Individuals who are homozygous for the allele GSTP1* B (coding for GSTP 1-1/V-105) display a higher susceptibility to malignancy because of other factors than a decreased catalytic efficiency of GSTP2-1-1 or V-105 in the detoxication of carcinogenic diol epoxides of benzo[a]pyrene or structurally related PAH. Expand
Carbonyl reductase provides the enzymatic basis of quinone detoxication in man.
The broad specificity of carbonyl reduct enzyme for quinones is in keeping with a role of the enzyme as a general quinone reductase in the catabolism of these compounds. Expand
Cancer initiation by polycyclic aromatic hydrocarbons results from formation of stable DNA adducts rather than apurinic sites.
Stable DNA adducts rather than AP sites are responsible for tumor initiation by carcinogenic PAHs, with the most potent carcinogen, DB[a,l]P, induced the highest level of stableAdducts and the lowest level of AP sites in epidermal DNA. Expand
Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate.
In conclusion, apart from the modulation of detoxifying enzymes in the intestine, induction of BCRP by dietary constituents may contribute to the detoxification of food-derived procarcinogens such as BP. Expand
Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.
Findings indicate that the exceptional tumorigenic potency of B[c]Ph or related fjord region diol-epoxides may be attributed, at least in part, to slow repair of the stable base adducts deriving from the reaction of these compounds with DNA. Expand
Mainstream smoke of the waterpipe: does this environmental matrix reveal as significant source of toxic compounds?
High amounts of unburned humectants (glycerol and propylene glycol) in the waterpipe smoke as main part of the so-called "tar" fraction give cause for serious concern. Expand
Polycyclic aromatic hydrocarbons stimulate human CYP3A4 promoter activity via PXR.
Results show that both PAH parent compounds as well as their phase I metabolites induce CYP3A4 promoter via the transcription factor PXR. Expand